Intracranial Calcification Detection; a Comparison Between Micro-CT, Conventional CT and Ultra-high-resolution Photon-Counting Detector CT.

IF 3.8 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Academic Radiology Pub Date : 2025-02-12 DOI:10.1016/j.acra.2025.01.028

Judith van der Bie, Bernhard P Berghout, Ricardo P J Budde, Jose Gutierrez, Marcel van Straten, Daniel Bos

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引用次数: 0

Abstract

Rationale and objectives: To evaluate the performance of photon-counting detector CT (PCD-CT) in identifying and quantifying intracranial calcifications compared to conventional energy-integrating CT (EID-CT), utilizing micro-CT (µCT) as benchmark.

Method: Thirty cross-sectional histopathological samples of the intracranial arteries were scanned using PCD-CT, EID-CT and µCT. Scans were optimized for µCT for maximum image quality, while clinical protocols were followed for PCD-CT and EID-CT. Additional reconstruction kernels (EID-CT: Hv40/Hv49/Hv59, PCD-CT: Hv40/Hv48/Hv56/Hv64/Hv72/Hv89) were used to enhance the spatial resolution. Two observers evaluated calcification presence subjectively, using Cohen's kappa (κ) and concordance percentages. Mass scores were utilized to objectively analyze calcium detection using intraclass correlation coefficients and Bland-Altman plots.

Results: Observer 1 detected calcifications in 24 samples and Observer 2 in 23 samples using µCT (90% concordance, κ=0.706). The highest agreement was with EID-CT Hv59 (97% concordance, κ=0.911), but calcium detection rates were low (observer 1; 27%, observer 2: 25%) compared to µCT. The most optimal results of calcium detection were obtained with PCD-CT Hv48 (observer 1: concordance=90%, κ=0.706) and PCD-CT Hv56 (observer 2: concordance 77%, κ=0.314) compared to μCT. Mass scores revealed the highest detection rate with PCD-CT Hv64 but also increased noise levels compared to softer kernels (

Conclusion: PCD-CT outperformed EID-CT in detecting intracranial calcifications compared to µCT. Reconstructions with Hv48 or Hv56 kernels are recommended, considering the noise increase with sharper kernels.

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来源期刊

Academic Radiology 医学-核医学

CiteScore

7.60

自引率

10.40%

发文量

432

审稿时长

18 days

期刊介绍： Academic Radiology publishes original reports of clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, image-guided interventions and related techniques. It also includes brief technical reports describing original observations, techniques, and instrumental developments; state-of-the-art reports on clinical issues, new technology and other topics of current medical importance; meta-analyses; scientific studies and opinions on radiologic education; and letters to the Editor.