Risk of Vulvar HSIL and Penile Neoplasias in Anogenital Lichen Planus: A Case-Control Study.

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY Journal of Lower Genital Tract Disease Pub Date : 2025-07-01 Epub Date: 2025-02-14 DOI:10.1097/LGT.0000000000000879

Niina K Hieta, Lotta Tapana, Jenni M Söderlund, Jutta K Huvila, Lauri A I Talve, Marjut A M Haataja

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Abstract

Objective: Lichen planus (LP) is a chronic inflammatory skin disease that may affect the skin, scalp, nails, and mucosa. The aim of this study was to investigate the risk of genital premalignant and malignant conditions in patients with anogenital LP (agLP).

Methods: The authors identified 60 male and 56 female patients with agLP by searching the biobank archives for a genital or perianal skin biopsy showing LP between 2004 and 2020. They also included 10 randomly selected age- and sex-matched controls for each patient. The risks of genital cancers and their precursors were evaluated.

Results: The incidence of agLP was 1.54 per 100,000 men and 1.36 per 100,000 women. There was no statistical difference between male and female incidence ( p = .5721). The odds ratio (OR) for high-grade squamous intraepithelial lesion (HSIL) of the vulva was 31.2 (95% CI = 2.46-1645.00; p = .01). The OR for penile neoplasias could not be calculated because control patients had no neoplasias, but the difference was suggestive of statistical significance (95% CI = 1.90-infinite; p = .008). The mean age at the time of diagnosis of agLP was 59.9 years (median 62 years) in female patients and 40.8 years (median 33 years) in male patients. The difference in the mean ages of female and male patients was statistically significant (95% CI = 11.92-26.13; p < .001).

Conclusions: Patients with agLP may have an increased risk for vulvar HSIL and penile neoplasia.

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阴部扁平苔藓外阴HSIL和阴茎瘤变的风险：一项病例对照研究。

目的：扁平苔藓（LP）是一种慢性炎症性皮肤病，可影响皮肤、头皮、指甲和粘膜。本研究的目的是调查肛门生殖器LP （agLP）患者的生殖器癌前病变和恶性病变的风险。方法：我们通过检索2004年至2020年间显示LP的生殖器或肛周皮肤活检的生物库档案，确定了60名男性和56名女性agLP患者。我们还为每位患者随机选择了10名年龄和性别匹配的对照组。评估了生殖器癌及其前体的风险。结果：男性agLP发病率为1.54 / 10万，女性为1.36 / 10万。男女发病率无统计学差异（p = .5721）。外阴高度鳞状上皮内病变（HSIL）的优势比（OR）为31.2 (95% CI = 2.46-1645.00；P = 0.01)。由于对照组患者未发生阴茎肿瘤，故无法计算阴茎肿瘤的OR，但差异具有统计学意义(95% CI = 1.90-infinite；P = .008)。女性患者诊断为agLP时的平均年龄为59.9岁（中位62岁），男性患者为40.8岁（中位33岁）。男女患者的平均年龄差异有统计学意义(95% CI = 11.92 ~ 26.13；P < 0.001)。结论：agLP患者发生外阴HSIL和阴茎肿瘤的风险增加。

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来源期刊

Journal of Lower Genital Tract Disease OBSTETRICS & GYNECOLOGY-

CiteScore

6.80

自引率

8.10%

发文量

158

审稿时长

6-12 weeks

期刊介绍： The Journal of Lower Genital Tract Disease is the source for the latest science about benign and malignant conditions of the cervix, vagina, vulva, and anus. The Journal publishes peer-reviewed original research original research that addresses prevalence, causes, mechanisms, diagnosis, course, treatment, and prevention of lower genital tract disease. We publish clinical guidelines, position papers, cost-effectiveness analyses, narrative reviews, and systematic reviews, including meta-analyses. We also publish papers about research and reporting methods, opinions about controversial medical issues. Of particular note, we encourage material in any of the above mentioned categories that is related to improving patient care, avoiding medical errors, and comparative effectiveness research. We encourage publication of evidence-based guidelines, diagnostic and therapeutic algorithms, and decision aids. Original research and reviews may be sub-classified according to topic: cervix and HPV, vulva and vagina, perianal and anal, basic science, and education and learning. The scope and readership of the journal extend to several disciplines: gynecology, internal medicine, family practice, dermatology, physical therapy, pathology, sociology, psychology, anthropology, sex therapy, and pharmacology. The Journal of Lower Genital Tract Disease highlights needs for future research, and enhances health care. The Journal of Lower Genital Tract Disease is the official journal of the American Society for Colposcopy and Cervical Pathology, the International Society for the Study of Vulvovaginal Disease, and the International Federation of Cervical Pathology and Colposcopy, and sponsored by the Australian Society for Colposcopy and Cervical Pathology and the Society of Canadian Colposcopists.