Multidimensional charge-enhanced interface by skin-like inflammatory response for visual bacterial pre-diagnosis

Abstract

Visual diagnosis techniques can provide intuitive results for detecting bacterial infection of wound, where the detection speed and intuitiveness directly affect the treatment efficiency. Here, we present a bionic charge-enhanced interface (BCEI), and show the utility to reverse the visual preclinical diagnosis of bacterial infections. The BCEI inspired by skin-like immune emergency response that achieve the fast, accurate, and portable visual identification of bacterial metabolites by multidimensional design and charge-enhanced effect. Aim to enable a strong adsorption and immobilization of gases markers of inflammatory response, in which it provides a 60 % improvement in color change (White turns to black) capability for detecting bacterial metabolic Hydrogen sulfide (H₂S) gas, a 37.5 % reduction in response time and a detection limit as low as 0.5 ppm. The detection capability of (E. coli infection group) and (S. aureus infection group) is improved by 65 % and 20 %, respectively. Furthermore, develop a wound status early warning system for visual bacterial pre-diagnosis, enabling to access wound conditions timely, accurately, and provide remote diagnosis.