{"title":"Closing the loop with reactions at the N-terminus","authors":"Kejia Yan, Ratmir Derda","doi":"10.1038/s41570-025-00697-4","DOIUrl":null,"url":null,"abstract":"Recently developed chemical and enzymatic methods to cyclize peptides in already prepared genetically encoded libraries enable the rapid exploration of new cyclic peptide topologies.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"48 1","pages":""},"PeriodicalIF":38.1000,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature reviews. Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1038/s41570-025-00697-4","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Recently developed chemical and enzymatic methods to cyclize peptides in already prepared genetically encoded libraries enable the rapid exploration of new cyclic peptide topologies.
期刊介绍：
Nature Reviews Chemistry is an online-only journal that publishes Reviews, Perspectives, and Comments on various disciplines within chemistry. The Reviews aim to offer balanced and objective analyses of selected topics, providing clear descriptions of relevant scientific literature. The content is designed to be accessible to recent graduates in any chemistry-related discipline while also offering insights for principal investigators and industry-based research scientists. Additionally, Reviews should provide the authors' perspectives on future directions and opinions regarding the major challenges faced by researchers in the field.
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