Pub Date : 2026-02-06DOI: 10.1038/s41570-026-00803-0
Stuart Schreiber, Stephanie Greed
{"title":"A conversation with a chemical biology pioneer.","authors":"Stuart Schreiber, Stephanie Greed","doi":"10.1038/s41570-026-00803-0","DOIUrl":"https://doi.org/10.1038/s41570-026-00803-0","url":null,"abstract":"","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":" ","pages":""},"PeriodicalIF":51.7,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-06DOI: 10.1038/s41570-026-00798-8
Oskar Karlsson, Berit Olofsson, Aji P Mathew
{"title":"A call for chemical safety and sustainability.","authors":"Oskar Karlsson, Berit Olofsson, Aji P Mathew","doi":"10.1038/s41570-026-00798-8","DOIUrl":"https://doi.org/10.1038/s41570-026-00798-8","url":null,"abstract":"","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":" ","pages":""},"PeriodicalIF":51.7,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Substitution is a vital strategy for developing high-performance sodium layered oxides (SLOs), which demonstrates great potential for making sodium-ion batteries a viable alternative to lithium-ion batteries. Numerous studies have been conducted on substituted SLOs; however, each substitute exhibits varied effects on the structure and electrochemical performance of the SLOs, and no clear design principles have been established. Clarifying the relationship among substitution, structure and performance is therefore important to enable a rational design strategy for high-performance SLOs. In this Review, the up-to-date substitution guidelines and the current understanding of how substitution affects the structure and electrochemistry in SLOs are discussed, and the site preference and characteristic redox features of different types of substitutes are outlined. The inherent challenges and opportunities for the innovation of better-performing SLOs are summarized, paving the way for accelerating the commercialization of SLO-based sodium-ion batteries and the realization of their applications ranging from electric vehicles to grid energy storage systems.
{"title":"Substitution and electrochemistry in layered oxide cathode materials for sodium-ion batteries.","authors":"Liangtao Yang,Xingxing Yin,Jun Wang,Yanan Sun,Yongchun Li,Zhenggang Zhang,Zhongqing Liu,Si-Min Huang,Philipp Adelhelm,Dong Zhou","doi":"10.1038/s41570-025-00795-3","DOIUrl":"https://doi.org/10.1038/s41570-025-00795-3","url":null,"abstract":"Substitution is a vital strategy for developing high-performance sodium layered oxides (SLOs), which demonstrates great potential for making sodium-ion batteries a viable alternative to lithium-ion batteries. Numerous studies have been conducted on substituted SLOs; however, each substitute exhibits varied effects on the structure and electrochemical performance of the SLOs, and no clear design principles have been established. Clarifying the relationship among substitution, structure and performance is therefore important to enable a rational design strategy for high-performance SLOs. In this Review, the up-to-date substitution guidelines and the current understanding of how substitution affects the structure and electrochemistry in SLOs are discussed, and the site preference and characteristic redox features of different types of substitutes are outlined. The inherent challenges and opportunities for the innovation of better-performing SLOs are summarized, paving the way for accelerating the commercialization of SLO-based sodium-ion batteries and the realization of their applications ranging from electric vehicles to grid energy storage systems.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"1 1","pages":""},"PeriodicalIF":36.3,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1038/s41570-026-00800-3
Jane Richardson, Stephanie Greed
Ahead of her 85th birthday, Jane Richardson, Professor of Biochemistry at Duke University, discussed her life in science from making her own telescope to developing the ribbon diagrams for the 3D structure of proteins.
{"title":"Stories from the scientist who changed how we visualize proteins","authors":"Jane Richardson, Stephanie Greed","doi":"10.1038/s41570-026-00800-3","DOIUrl":"10.1038/s41570-026-00800-3","url":null,"abstract":"Ahead of her 85th birthday, Jane Richardson, Professor of Biochemistry at Duke University, discussed her life in science from making her own telescope to developing the ribbon diagrams for the 3D structure of proteins.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 2","pages":"99-100"},"PeriodicalIF":51.7,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146056745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1038/s41570-026-00796-w
Xuan Ji, Yueqi Chen, Xi Yu, Christian A. Nijhuis
Non-steady-state chemical dynamics offer a powerful tool for neuromorphic computing by harnessing nonlinear, collective, and time-evolving behaviours. Coupled with frameworks such as reservoir computing, these systems enable trajectory-based information processing at the molecular scale through concepts from chemical kinetics and far-from-equilibrium dynamics.
{"title":"Making chemistry compute with non-steady-state chemical dynamics","authors":"Xuan Ji, Yueqi Chen, Xi Yu, Christian A. Nijhuis","doi":"10.1038/s41570-026-00796-w","DOIUrl":"10.1038/s41570-026-00796-w","url":null,"abstract":"Non-steady-state chemical dynamics offer a powerful tool for neuromorphic computing by harnessing nonlinear, collective, and time-evolving behaviours. Coupled with frameworks such as reservoir computing, these systems enable trajectory-based information processing at the molecular scale through concepts from chemical kinetics and far-from-equilibrium dynamics.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 2","pages":"92-94"},"PeriodicalIF":51.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1038/s41570-025-00792-6
Mira Todorova, Stefan Wippermann, Jörg Neugebauer
Ab initio techniques have revolutionized the way theory helps practitioners to explore mechanisms governing reactions or properties, and develop new strategies for materials discovery and design. Nevertheless, their application to electrochemical systems remains limited, due to challenges electronic structure calculations face in achieving realistic descriptions of electrified solid–liquid interfaces, including potential and pH control or free energies of barrier configurations. The extension of the scope of simulations to achieve potential control, inherent to electrochemical experiments, is just emerging. In this Review, we discuss approaches to describing electrified interfaces between solid electrodes and liquid electrolytes in realistic environments. By exchanging energy, electronic charge and ions with their environment, electrochemical interfaces are thermodynamically open systems. Additionally, large electrostatic potential and field fluctuations occur on timescales and length scales relevant to chemical reactions. We discuss the key challenges for incorporating these features into ab initio simulations to facilitate broader community use and provide a new level of realism when exploring fundamental electrochemistry from first principles. State-of-the-art approaches for modelling electrified solid–electrolyte interfaces are critically discussed, highlighting key challenges in incorporating thermodynamic open-boundary conditions, large electrostatic potentials and their dynamic fluctuations into realistic ab initio simulations.
{"title":"First-principles approaches and concepts to simulate electrochemical interfaces","authors":"Mira Todorova, Stefan Wippermann, Jörg Neugebauer","doi":"10.1038/s41570-025-00792-6","DOIUrl":"10.1038/s41570-025-00792-6","url":null,"abstract":"Ab initio techniques have revolutionized the way theory helps practitioners to explore mechanisms governing reactions or properties, and develop new strategies for materials discovery and design. Nevertheless, their application to electrochemical systems remains limited, due to challenges electronic structure calculations face in achieving realistic descriptions of electrified solid–liquid interfaces, including potential and pH control or free energies of barrier configurations. The extension of the scope of simulations to achieve potential control, inherent to electrochemical experiments, is just emerging. In this Review, we discuss approaches to describing electrified interfaces between solid electrodes and liquid electrolytes in realistic environments. By exchanging energy, electronic charge and ions with their environment, electrochemical interfaces are thermodynamically open systems. Additionally, large electrostatic potential and field fluctuations occur on timescales and length scales relevant to chemical reactions. We discuss the key challenges for incorporating these features into ab initio simulations to facilitate broader community use and provide a new level of realism when exploring fundamental electrochemistry from first principles. State-of-the-art approaches for modelling electrified solid–electrolyte interfaces are critically discussed, highlighting key challenges in incorporating thermodynamic open-boundary conditions, large electrostatic potentials and their dynamic fluctuations into realistic ab initio simulations.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 2","pages":"133-146"},"PeriodicalIF":51.7,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146033869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1038/s41570-026-00797-9
João Avó, Carina I. C. Crucho
In an era of global transition, new frontiers in chemistry — from space mining to circular technologies — are poised to reshape global power. This Comment explores how future supply chains, strategic resources, and chemistry could define the next era of geopolitical competition.
{"title":"The geopolitical future for chemistry","authors":"João Avó, Carina I. C. Crucho","doi":"10.1038/s41570-026-00797-9","DOIUrl":"10.1038/s41570-026-00797-9","url":null,"abstract":"In an era of global transition, new frontiers in chemistry — from space mining to circular technologies — are poised to reshape global power. This Comment explores how future supply chains, strategic resources, and chemistry could define the next era of geopolitical competition.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 2","pages":"95-96"},"PeriodicalIF":51.7,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146033870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1038/s41570-025-00790-8
Jarla Thiesbrummel,Jovana V Milić,Carsten Deibel,Erik C Garnett,Shuxia Tao,Thomas Kirchartz,Antonio Guerrero,Petra Cameron,Wolfgang Tress,M Saiful Islam,Bruno Ehrler
Metal halide perovskite solar cells have considerable potential for next-generation solar power production. However, if not controlled, the migration of mobile ions can hamper the stability of perovskite solar cells. Intensive research efforts have devised methods of suppressing ion migration and degradation in perovskite materials, resulting in solar cells that are stable over thousands of hours during accelerated ageing testing. Here, we review the chemical origins of ion migration, its effect on material and device performance and stability, and strategies to mitigate its impact. Ion migration originates in the soft lattice of the halide perovskite framework and its low defect-formation energy, but there are many different strategies to reduce its effects, from compositional engineering of materials and device architecture changes to additives and strain engineering. The field has made great progress in understanding the origin and properties of mobile ions in halide perovskites and has improved operational stability beyond expectations. Nonetheless, there are still ample opportunities to further improve the long-term durability of perovskite solar cells, either by reducing ion migration or its effect on solar cell efficiency.
{"title":"Ion migration in perovskite solar cells.","authors":"Jarla Thiesbrummel,Jovana V Milić,Carsten Deibel,Erik C Garnett,Shuxia Tao,Thomas Kirchartz,Antonio Guerrero,Petra Cameron,Wolfgang Tress,M Saiful Islam,Bruno Ehrler","doi":"10.1038/s41570-025-00790-8","DOIUrl":"https://doi.org/10.1038/s41570-025-00790-8","url":null,"abstract":"Metal halide perovskite solar cells have considerable potential for next-generation solar power production. However, if not controlled, the migration of mobile ions can hamper the stability of perovskite solar cells. Intensive research efforts have devised methods of suppressing ion migration and degradation in perovskite materials, resulting in solar cells that are stable over thousands of hours during accelerated ageing testing. Here, we review the chemical origins of ion migration, its effect on material and device performance and stability, and strategies to mitigate its impact. Ion migration originates in the soft lattice of the halide perovskite framework and its low defect-formation energy, but there are many different strategies to reduce its effects, from compositional engineering of materials and device architecture changes to additives and strain engineering. The field has made great progress in understanding the origin and properties of mobile ions in halide perovskites and has improved operational stability beyond expectations. Nonetheless, there are still ample opportunities to further improve the long-term durability of perovskite solar cells, either by reducing ion migration or its effect on solar cell efficiency.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"86 1","pages":""},"PeriodicalIF":36.3,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146015392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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