Wangyu Li, Shiwen Zhou, He Tang, Fengjian Chu, Hongru Feng, Yuan-Jiang Pan
{"title":"A Mild Reductant NHC‐ligated Borane for N‑Formylation of Amines with CO2 under Ambient Conditions","authors":"Wangyu Li, Shiwen Zhou, He Tang, Fengjian Chu, Hongru Feng, Yuan-Jiang Pan","doi":"10.1002/adsc.202401384","DOIUrl":null,"url":null,"abstract":"A convenient and efficient metal‐free protocol has been reported for formylation of various amines with carbon dioxide. This reaction could proceed under ambient conditions and show a broad substrate scope, encompassing primary amines, secondary amines, chiral amino acid esters and bioactive molecules. Furthermore, this method offers several advantages, including the preservation of substrate chirality, ease of separation and purification and the suitability of formic acid and formate salts as reactants in this reaction.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"64 1","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/adsc.202401384","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
A convenient and efficient metal‐free protocol has been reported for formylation of various amines with carbon dioxide. This reaction could proceed under ambient conditions and show a broad substrate scope, encompassing primary amines, secondary amines, chiral amino acid esters and bioactive molecules. Furthermore, this method offers several advantages, including the preservation of substrate chirality, ease of separation and purification and the suitability of formic acid and formate salts as reactants in this reaction.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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