Phyto-fabrication and characterization of ZnFe2O4@AC nanocomposite catalyst via green pathway and its application for the synthesis of some Quinazolin-4(1H)-one derivatives

Abstract

Green fabrication of nanocatalyst have been used in numerous organic reactions, due to its admirable catalytical, electrical, and mechanical properties. Especially, phyto-fabrication of carbon supported nanocatalyst achieved exceptional yield with small amount of catalyst loading in organic transformations, this unique nature of catalyst based on reactivity and renewability makes this material as an efficient, outstanding, and ecofriendly nanocatalyst. In the present study, ZnFe₂O₄@AC nanocomposites (NCs) were synthesized by co-precipitation method using leaves extract of Careya arborea. Moreover, synthesized ZnFe₂O₄@AC NCs were characterized by XRD, EDS, FE-SEM and HR-TEM. The XRD reveals cubic phase with high crystallinity. While, EDS analysis confirmed elemental purity of the ZnFe₂O₄@AC NCs and showed the carbon blending. However, HR-TEM images shown the cubic shape with an average size in the range of 18–22 nm. The obtained ZnFe₂O₄@AC NCs shows catalytic properties, which is applicable for organic transformation of derivatives of Quinazolin-4(1H)-one. These Quinazolin-4(1H)-one derivatives have been accomplished with single step reaction between aromatic aldehydes and 2-aminobenzamide at room temperature. Different aromatic aldehydes substrates were used for the preparation of Quinazolin-4(1H)-one derivatives. The spectroscopic data of FT-IR, ¹H NMR and ¹³C NMR authenticates the formation of Quinazolin-4(1H)-one derivatives. Synthetic data of derivatives demonstrated that 20 mg of catalyst loading achieved remarkable 96 % yield in ethanol. The outcomes of the prepared derivatives confirm the purity of the organic compound, which offering protocol for organic transformation have some potential features such as a simple procedure, short reaction time, mild reaction conditions, easy workup, and high yield of products.