{"title":"Twenty years in metalloprotein bioinformatics: A short history of a long journey","authors":"Claudia Andreini","doi":"10.1016/j.jinorgbio.2025.112854","DOIUrl":null,"url":null,"abstract":"<div><div>The study of the structure and function of metalloproteins is a central subject of inorganic biochemistry. Starting from the 2000s, computational methods have flanked experimental research by exploiting the ever-increasing computing power and the huge amount of data produced by omics technologies. In this article, we retrace the major advancements that brought bioinformatics from being of minor relevance to being an essential tool for today's inorganic biochemists, focusing on the contributions coming from the Magnetic Resonance Center (CERM) of Florence, where we have been developing for twenty years methods and resources to investigate metalloproteins with computational approaches.</div></div>","PeriodicalId":364,"journal":{"name":"Journal of Inorganic Biochemistry","volume":"266 ","pages":"Article 112854"},"PeriodicalIF":3.2000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Inorganic Biochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0162013425000340","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/11 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The study of the structure and function of metalloproteins is a central subject of inorganic biochemistry. Starting from the 2000s, computational methods have flanked experimental research by exploiting the ever-increasing computing power and the huge amount of data produced by omics technologies. In this article, we retrace the major advancements that brought bioinformatics from being of minor relevance to being an essential tool for today's inorganic biochemists, focusing on the contributions coming from the Magnetic Resonance Center (CERM) of Florence, where we have been developing for twenty years methods and resources to investigate metalloproteins with computational approaches.
期刊介绍：
The Journal of Inorganic Biochemistry is an established international forum for research in all aspects of Biological Inorganic Chemistry. Original papers of a high scientific level are published in the form of Articles (full length papers), Short Communications, Focused Reviews and Bioinorganic Methods. Topics include: the chemistry, structure and function of metalloenzymes; the interaction of inorganic ions and molecules with proteins and nucleic acids; the synthesis and properties of coordination complexes of biological interest including both structural and functional model systems; the function of metal- containing systems in the regulation of gene expression; the role of metals in medicine; the application of spectroscopic methods to determine the structure of metallobiomolecules; the preparation and characterization of metal-based biomaterials; and related systems. The emphasis of the Journal is on the structure and mechanism of action of metallobiomolecules.
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