Progress of metal-organic frameworks in improving the effect of sonodynamic therapy

Abstract

Sonodynamic therapy (SDT) is a new non-invasive and precise tumor treatment method, which is a promising anticancer treatment and is becoming a cutting-edge interdisciplinary research field. Based on the research progress of SDT, this paper reviews the latest situation of metal-organic frameworks (MOF) based sonosensitizer in recent years, and introduces the preparation methods and related properties of MOF materials. By describing the many in-depth observations and understandings of MOF-assisted SDT strategies in anticancer applications, we aim to highlight the advantages and improvements of MOF-enhanced SDT and synergistic therapy. The methods to improve the effect of SDT were discussed by exploring the measures of combining hypoxia activating drugs, improving hypoxia microenvironment, accelerating glutathione consumption, and enhancing cavitation effect. Based on the extensive application of MOF materials in SDT and the related technical challenges, this review hopes to bring some enlightenment to improve the therapeutic effect of cancer and promote the development of nanomedicine.