Chen Guo, Jingjing Huang, Xiaoyang Hu, Qiong Li, Yinuo Song, Duo Peng, Kang Ning, Xiaoyan Wang, Dabing Zhang
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引用次数: 0
Abstract
Gosling gout is usually considered to be caused by goose astrovirus 2 (GoAstV-2); however, goose astrovirus 3 (GoAstV-3) has also been shown to play a pathogenic role in this disease. Here, we developed new assays for specific detection of goose astroviruses, including GoAstV-2- and GoAstV-3-specific reverse transcription (RT)-PCR and real-time fluorescence quantitative PCR (RT-qPCR) assays. These assays revealed coinfection with GoAstV-2 and GoAstV-3 in 19 (57.6%) out of 33 cases examined, with GoAstV-2 producing 1,000- to 100,000-fold higher viral loads than GoAstV-3. These findings will stimulate further studies on the roles of GoAstV-2 and GoAstV-3 in the occurrence of gosling gout.
期刊介绍：
Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.
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