Alkylated Quinolines through Benzylic sp3 C−H Functionalization: Sequential Synthesis and Photophysical Studies

Abstract

An efficient method has been developed for the green synthesis of alkylated quinolines via Cu‐TEMPO catalyzed dehydrogenation, and DEP/DES‐assisted benzylic C−H functionalization followed by cross Rauhut‐Currier type reaction. The reaction mechanism is elucidated through control experiments and ¹H NMR reaction monitoring. This transformation offers several advantages, including moderate to good yields of the desired products, mild reaction conditions, use of a cost‐effective metal catalyst, good functional group tolerance, and applicability to gram‐scale synthesis. Additionally, the synthetic utility and the photophysical properties of the synthesized alkylated quinoline derivatives were investigated.