Alkylated Quinolines through Benzylic sp3 C−H Functionalization: Sequential Synthesis and Photophysical Studies

Abstract

An efficient method has been developed for the green synthesis of alkylated quinolines via Cu-TEMPO catalyzed dehydrogenation, and DEP/DES-assisted benzylic C−H functionalization followed by cross Rauhut-Currier type reaction. The reaction mechanism is elucidated through control experiments and ¹H NMR reaction monitoring. This transformation offers several advantages, including moderate to good yields of the desired products, mild reaction conditions, use of a cost-effective metal catalyst, good functional group tolerance, and applicability to gram-scale synthesis. Additionally, the synthetic utility and the photophysical properties of the synthesized alkylated quinoline derivatives were investigated.