Differential Impact of Metabolic Factors and Comorbidities on Peripheral Neuropathy

IF 3 3区医学 Q1 CLINICAL NEUROLOGY Journal of the Peripheral Nervous System Pub Date : 2025-02-14 DOI:10.1111/jns.70004

Georgios Ponirakis, Ioannis N. Petropoulos, Hoda Gad, Sidra Abdulshakoor, Jenneth M. Concepcion, Sara H. Khalfalla, Iynas S. A. Elamin, Abeer T. H. AlZawqari, Einas Elgassim, Areej Baraka, Aljazi M. Al-Khalifa, Ziyad R. Mahfoud, Marwa A. El Deeb, Nahla Afifi, Rayaz A. Malik

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Abstract

Objective

This study aimed to assess the impact of metabolic factors and comorbidities on peripheral neuropathy.

Methods

Qatari nationals and long-term residents from the Qatar Biobank underwent clinical/metabolic assessments, including iDXA to measure visceral adipose tissue (VAT) and subcutaneous (SAT) volumes, inflammation, thyroid function, carotid intima media thickness (CIMT), corneal confocal microscopy (CCM), vibration perception threshold (VPT), and DN4 questionnaire.

Results

In 332 adults aged 43.4 ± 12.7 years, the prevalence of neuropathy was 3.9%. The prevalence of T2D was 16.6%, and the prevalence of neuropathy was significantly higher in T2D (14.5% vs. 1.8%, p < 0.0001). A higher HbA1c (p = 0.05) and lower eGFR (p < 0.01) were associated with reduced inferior whorl length (IWL) and lower FT3 was associated with reduced corneal nerve fiber length (CNFL) (p < 0.01). Triglycerides were associated with increased neuropathic symptoms (p = 0.05). All the risk factors in this study contributed to 39% of neuropathy in T2D but had a minimal impact in those without T2D.

Conclusions

This study highlights the importance of additional risk factors beyond traditional risk factors associated with peripheral neuropathy in T2D.

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代谢因素和合并症对周围神经病变的不同影响

目的探讨代谢因素及合并症对周围神经病变的影响。方法来自卡塔尔生物银行的卡塔尔国民和长期居民进行了临床/代谢评估，包括iDXA测量内脏脂肪组织（VAT）和皮下（SAT）体积、炎症、甲状腺功能、颈动脉内膜中膜厚度（CIMT）、角膜共聚焦显微镜（CCM）、振动感知阈值（VPT）和DN4问卷。结果332例成人（43.4±12.7岁），神经病变发生率为3.9%。T2D患病率为16.6%，神经病变患病率明显高于T2D （14.5% vs. 1.8%, p < 0.0001）。较高的HbA1c （p = 0.05）和较低的eGFR （p < 0.01）与下轮长度（IWL）减少有关，较低的FT3与角膜神经纤维长度（CNFL）减少有关（p < 0.01）。甘油三酯与神经病变症状增加相关（p = 0.05）。本研究中所有的危险因素导致了39%的T2D患者的神经病变，但对非T2D患者的影响最小。结论：本研究强调了与T2D周围神经病变相关的传统危险因素之外的其他危险因素的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Peripheral Nervous System 医学-临床神经学

CiteScore

6.10

自引率

7.90%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of the Peripheral Nervous System is the official journal of the Peripheral Nerve Society. Founded in 1996, it is the scientific journal of choice for clinicians, clinical scientists and basic neuroscientists interested in all aspects of biology and clinical research of peripheral nervous system disorders. The Journal of the Peripheral Nervous System is a peer-reviewed journal that publishes high quality articles on cell and molecular biology, genomics, neuropathic pain, clinical research, trials, and unique case reports on inherited and acquired peripheral neuropathies. Original articles are organized according to the topic in one of four specific areas: Mechanisms of Disease, Genetics, Clinical Research, and Clinical Trials. The journal also publishes regular review papers on hot topics and Special Issues on basic, clinical, or assembled research in the field of peripheral nervous system disorders. Authors interested in contributing a review-type article or a Special Issue should contact the Editorial Office to discuss the scope of the proposed article with the Editor-in-Chief.