A Sustainable Catalyst‐Free Approach to Bipyrazoles Under Batch and Flow Chemistry Techniques

IF 2.8 4区 化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2025-02-01 DOI:10.1002/ajoc.202400583
Akanksha Kumari , Anshul Jain , Dr. Nirmal K. Rana
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Abstract

We have developed an efficient and sustainable approach for the synthesis of 4,4′‐bipyrazole derivatives from spirocyclopropanyl‐pyrazolone and hydrazine under mild conditions. This methodology is catalyst‐free, operating effectively in both batch and continuous flow processes. The flow synthesis allows the production of products up to 110 mg/h which provides industrial applicability and scalability. Additionally, 4,4’‐bipyraole has been transformed into a triphenyl‐substituted pyrazole derivative.
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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
期刊最新文献
Front Cover: Synthesis of 2H-1,4-Oxazin-3(4H)-One Utilizing Umpolung Reaction to α-Hydrazonoketone (Asian J. Org. Chem. 3/2025) Visible‐Light‐Induced Carbopyridylation of Maleimides with Pyridine Salts Under Catalyst‐Free Conditions A Promising Strategy for Searching High Energy Density Materials Based on 2,4,5‐Trinitro‐Imidazole Functional Backbone Synthesis of 2H‐1,4‐Oxazin‐3(4H)‐One Utilizing Umpolung Reaction to α‐Hydrazonoketone Deacylation of N‐Acylsulfonamides Mediated by Metal Triflimides
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