{"title":"Light-Induced Tetrafluoroethylation/Cyclization of N-Methacryloyl-2-phenylbenzoimidazoles with 1,2-Dibromotetrafluoroethane","authors":"Zhoubin Deng, Yuyu Lv, Ke-Hu Wang, Danfeng Huang, Junjiao Wang, Yulai Hu","doi":"10.1002/ajoc.202400620","DOIUrl":null,"url":null,"abstract":"<p>Various <i>N</i>-methacryloyl-2-arylbenzoimidazoles react with 1,2-dibromotetrafluoroethane in the presence of photocatalyst 4CzIPN irradiated by 10 W blue LED to provide 5-(3-bromo-2,2,3,3-tetrafluoropropyl)-5-methylbenzo[4,5]-imidazo[2,1-a]isoquinolin-6(5<i>H</i>)-ones in good yield. The reaction proceeds through a sequential tetrafluoroethyl radical addition/cyclization pathway. The wide substrate scope, good functional group tolerance, and ease of scale-up of this protocol are expected to promote its potential applications in pharmacy.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 2","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://aces.onlinelibrary.wiley.com/doi/10.1002/ajoc.202400620","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Various N-methacryloyl-2-arylbenzoimidazoles react with 1,2-dibromotetrafluoroethane in the presence of photocatalyst 4CzIPN irradiated by 10 W blue LED to provide 5-(3-bromo-2,2,3,3-tetrafluoropropyl)-5-methylbenzo[4,5]-imidazo[2,1-a]isoquinolin-6(5H)-ones in good yield. The reaction proceeds through a sequential tetrafluoroethyl radical addition/cyclization pathway. The wide substrate scope, good functional group tolerance, and ease of scale-up of this protocol are expected to promote its potential applications in pharmacy.
期刊介绍：
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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