{"title":"Review: New strategies for early dietary intervention in Alzheimer's disease","authors":"Jinyan Huang","doi":"10.1016/j.nupar.2024.11.002","DOIUrl":null,"url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a neurodegenerative disorder for which the cause is currently unknown, which has implications for drug development. In recent years, blood biomarkers have shown great potential in the early diagnosis of AD, and rapid advances in disease-modifying therapies have opened new possibilities for early treatment. In this article, we review the latest research on biomarkers related to Alzheimer's diagnosis and discuss the prospects of preclinical interventions, such as the use of natural extracts and probiotics in disease-modifying therapies (DMTs) via the gut-brain axis and other pathways, which provide new ideas for future therapeutic strategies and management of Alzheimer's disease.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 1","pages":"Pages 15-21"},"PeriodicalIF":0.4000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Clinique et Metabolisme","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0985056224001432","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/24 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder for which the cause is currently unknown, which has implications for drug development. In recent years, blood biomarkers have shown great potential in the early diagnosis of AD, and rapid advances in disease-modifying therapies have opened new possibilities for early treatment. In this article, we review the latest research on biomarkers related to Alzheimer's diagnosis and discuss the prospects of preclinical interventions, such as the use of natural extracts and probiotics in disease-modifying therapies (DMTs) via the gut-brain axis and other pathways, which provide new ideas for future therapeutic strategies and management of Alzheimer's disease.
期刊介绍：
Nutrition Clinique et Métabolisme is the journal of the French-speaking Society of Enteral and Parenteral Nutrition. Associating clinicians, biologists, pharmacists, and fundamentalists, the articles presented in the journal concern man and animals, and deal with organs and cells. The goal is a better understanding of the effects of artificial nutrition and human metabolism. Original articles, general reviews, update articles, technical notes and communications are published, as well as editorials and case reports.
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