Urban-rural differences in age-specific mortality rates for breast cancer in China from 2009 to 2021

Abstract

Background

Breast cancer is the fifth leading cancer-related cause of death among women in China. With the advent of the “Two cancers screening” national health plan from 2009, we aim to present the change and rural-urban differences in age-specific mortality rates during 2009-2021.

Methods

We extracted age-specific mortality data of breast cancer by rural-urban residence for Chinese women aged 20-84 years from 2009 to 2021 from China’s National Disease Surveillance Points system. The population data covering 166.1 million of women were grouped as 20-34 years, 35-64 years, and 65-84 years. We used negative binomial regression models to assess mortality rate ratios between urban and rural (reference) by time-periods. We assessed temporal trends in age-specific mortality rates for breast cancer using log-linear Joinpoint models.

Findings

From 2009 to 2021, the mortality rates of breast cancer changed from 13.73 per 100,000 women to 10.08 per 100,000 women in urban women aged 35-64 years with an average annual percent change (AAPC) of − 2.7% (95% CI − 4.6 to − 0.7, P = 0.007) and from 10.81 per 100,000 women to 10.91 per 100,000 women in rural women aged 35-64 years with an AAPC of 0.3%, (95% CI: − 0.3 to 0.9, P = 0.28). We identified comparatively minimal mortality disparities of breast cancer between urban and rural areas in the 35-64 age group (rate ratio: 1.12), compared to differences noted in younger (20-34 years, rate ratio: 0.82) and older groups (65-84 years, rate ratio: 1.64). The results among women aged 20-84 showed that the breast cancer mortality is significantly higher in urban than in rural areas, stratifying by time-period (rate ratio: 1.32 in 2009-2013, 1.23 in 2013-2017, and 1.11 in 2017-2021) and region (rate ratio: 1.27 in Central, 1.15 in Western, and 1.14 in Eastern). The results in the screening age of 35-64 group showed similar trends with overall population stratified by time-period (rate ratio: 1.20 in 2009-2013, 1.18 in 2013-2017, and 1.05 in 2017-2021) and region (rate ratio: 1.20 in Central, 1.07 in Western, and 1.08 in Eastern).

Interpretation

We found that breast cancer mortality in urban women was higher than that of rural women, with a decreasing temporal trend in rural-urban difference. The narrowing gap in breast cancer mortality rates between urban and rural areas may be related to the convergence of lifestyles in terms of reproduction, hormones, and other breast cancer risk factors among urban and rural residents. As socio-economic development and urbanization progress, differences in risk factors such as dietary patterns, lifestyles, and physical activity have become less pronounced nationwide, leading to a gradual reduction in the gap of breast cancer mortality rates between urban and rural women. This study provides insights into the changing landscape of breast cancer mortality in China, highlighting the need for continued efforts in screening and treatment, especially in urban areas where rates remain higher.