Diagnosis of neurological and non-neurological disorders via bimodal/multimodal imaging with lanthanide based nanoparticles

Abstract

To cure and extend life, it is essential to overcome age-related non-communicable disorders such as cancer, Alzheimer's disease, Huntington's disease, and Parkinson's disease in a shorter span of time. In this regard, the multimodal imaging technique can play a crucial role because it would significantly reduce the amount of drug needed for a patient by reducing the number of steps involved in a diagnosis. Additionally, it will provide a more accurate and precise diagnosis because the drawbacks of one particular modality can be overcome by complementary modality in a combined diagnosis instrument. This review discusses the commercially available MRI contrast agents and bimodal multimodal MRI-routed imaging with lanthanide-based nanoparticles (NPs), such as Optical/MRI, CT/MRI, and SPECT/MRI. Additionally, we also have discussed the progress of their multimodal imaging.