Recent advances in Schiff base coinage metal complexes as anticancer agents: A comprehensive review (2021–2025)

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED Dyes and Pigments Pub Date : 2025-02-15 DOI:10.1016/j.dyepig.2025.112710

Mohammed Fareed Felemban , Faris J. Tayeb , Ali Alqarni , Dr Amal Adnan Ashour , Dr Alaa Shafie

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Abstract

Cancer remains one of the most critical global health challenges, accounting for a substantial number of deaths worldwide. Conventional anticancer therapies, such as chemotherapy and radiation, are often accompanied by severe side effects, drug resistance, and limited specificity in targeting cancer cells, necessitating the development of novel, effective, and targeted therapeutic agents. Among the various strategies explored, metal-based drugs have attracted significant attention due to their unique chemical and biological properties. Schiff base compounds, with their versatile structural frameworks, have emerged as promising candidates in medicinal chemistry, owing to their ability to chelate metal ions and exhibit potent anticancer activities. In particular, Schiff base complexes with coinage metals (Cu, Ag and Au) have gained significant interest due to their unique redox properties, strong DNA-binding capabilities, and the ability to generate reactive oxygen species (ROS), which induce apoptosis in cancer cells. The aim of this review is to provide a comprehensive analysis of Schiff base coinage metal complexes, as potential anticancer agents. The review explores how the structural attributes of Schiff base ligands influence the biological activities of these complexes. Furthermore, recent advancements (2021–2025) in the development of these complexes are discussed, highlighting their efficacy against various cancer types and the specific advantages of incorporating coinage metals into Schiff base frameworks.

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.