Effects of Ciprofol and Propofol General Anesthesia on Postoperative Recovery Quality in Patients Undergoing Ureteroscopy: A Randomized, Controlled, Double-Blind Clinical Trial.

IF 5.1 2区医学 Q1 CHEMISTRY, MEDICINAL Drug Design, Development and Therapy Pub Date : 2025-02-11 eCollection Date: 2025-01-01 DOI:10.2147/DDDT.S497554

Shuqi Shi, Jimin Wu, Yini Wu, Xin Han, Hong Dai, Xuedong Chen, Zhangnan Sun, Faxing Wang

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Abstract

Objective: This study compares postoperative recovery quality between Ciprofol and Propofol, providing a reference for the clinical application of anesthetics.

Methods: We randomized 112 patients undergoing ureteroscopic surgery into two groups: the Ciprofol group (Group C), with an induction dose of 0.4 mg/kg and a maintenance dose of 0.8-1.5 mg/(kg·h), and the Propofol group (Group P), with an induction dose of 2 mg/kg and a maintenance dose of 4-10 mg/(kg·h). Both groups received sevoflurane at a concentration of 1%. The Bispectral Index (BIS) was maintained between 40 and 60. The primary outcomes were the Quality of Recovery-15 (QoR-15) scores on postoperative day 1 (POD1). Secondary outcomes included hemodynamic parameters, vasopressor use, timing indicators, sedative consumption, BIS values, Riker Sedation-Agitation Scale (R-SAS) scores, urinary tract symptoms, patient satisfaction, and adverse events.

Results: No significant differences were observed in QoR-15 scores between the two groups. Although Group C had higher pain (P = 0.004) and comfort (P = 0.002) scores on POD1, these differences were not clinically significant. The incidence of hypotension and vasopressor use was lower in Group C, which had more stable hemodynamics. Additionally, the time from induction to BIS ≤ 60 was shorter in Group P (P = 0.001), while Group C had lower BIS values from drug discontinuation to full recovery of consciousness (P = 0.001). The incidence of urinary tract symptoms on POD1 was lower in Group C (P = 0.043). There were no significant differences in time to spontaneous breathing recovery, extubation, recovery room stay, time to first ambulation, hospital stay, patient satisfaction, or other adverse events.

Conclusion: Ciprofol provides comparable early postoperative recovery to Propofol during ureteroscopy and may be a preferable alternative for urological procedures, especially in patients with blood pressure concerns.

Trial registration: Chinese Clinical Trial Registry (ChiCTR2400082736).

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环丙酚和异丙酚全身麻醉对输尿管镜术后患者恢复质量的影响：一项随机、对照、双盲临床试验。

目的：比较环丙酚与异丙酚的术后恢复质量，为麻醉药的临床应用提供参考。方法：将112例输尿管镜手术患者随机分为两组：环丙酚组（C组）诱导剂量为0.4 mg/kg，维持剂量为0.8 ~ 1.5 mg/(kg·h)；丙泊酚组（P组）诱导剂量为2 mg/kg，维持剂量为4 ~ 10 mg/（kg·h）。两组均注射浓度为1%的七氟醚。双谱指数（BIS）维持在40 ~ 60之间。主要结局是术后第1天的恢复质量-15 （QoR-15）评分。次要结局包括血流动力学参数、血管加压剂使用、定时指标、镇静剂使用、BIS值、Riker镇静-躁动量表（R-SAS）评分、尿路症状、患者满意度和不良事件。结果：两组患者QoR-15评分无显著差异。虽然C组患者在POD1上的疼痛（P = 0.004）和舒适（P = 0.002）评分较高，但这些差异无临床意义。C组低血压和血管加压药的发生率较低，血流动力学更稳定。此外，P组从诱导到BIS≤60的时间较短（P = 0.001），而C组从停药到完全恢复意识的BIS值较短（P = 0.001）。C组患者POD1尿路症状发生率较低（P = 0.043）。两组在自主呼吸恢复时间、拔管时间、恢复室停留时间、首次走动时间、住院时间、患者满意度或其他不良事件方面无显著差异。结论：输尿管镜检查时，环丙酚的术后早期恢复与异丙酚相当，可能是泌尿外科手术的首选选择，特别是对有血压问题的患者。试验注册：中国临床试验注册中心（ChiCTR2400082736）。

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来源期刊

Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

9.00

自引率

0.00%

发文量

382

审稿时长

>12 weeks

期刊介绍： Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.