Association between the atherogenic index of plasma and non-alcoholic fatty liver disease in Korean pregnant women: secondary analysis of a prospective cohort study.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS Frontiers in Nutrition Pub Date : 2025-01-31 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1511952

Rong Shuai, Yuxing He, Dongqian Yang, Yingying Zhang, Li Zhang

{"title":"Association between the atherogenic index of plasma and non-alcoholic fatty liver disease in Korean pregnant women: secondary analysis of a prospective cohort study.","authors":"Rong Shuai, Yuxing He, Dongqian Yang, Yingying Zhang, Li Zhang","doi":"10.3389/fnut.2025.1511952","DOIUrl":null,"url":null,"abstract":"Background: Recent studies have shown an association between atherogenic index of plasma (AIP) and nonalcoholic fatty liver disease (NAFLD), but the association in a population of pregnant women remains unclear.Objectives: Our study aimed to examine the association between AIP and NAFLD in pregnant Korean women.Methods: Our study used publicly available data from Korea, which recruited singleton pregnant women between November 2014 and September 2016 who were at 10-14 weeks of gestation. The presence of NAFLD was diagnosed by liver ultrasound. AIP was calculated as log10 (TG/HDL). Participants were grouped according to AIP tertile: T1 (< 0.16, n = 195), T2 (0.16-0.32, n = 195), and T3 (>0.32, n = 196). Logistic regression models were used to estimate the relationship between AIP and NAFLD. Subgroup and sensitivity analyses were conducted to explore the stability of this relationship. Restricted cubic spline (RCS) curve fitting was employed to investigate potential non-linear associations.Results: After excluding data on missing variables, 586 singleton pregnant women were finally included. The subjects included in the study had an average AIP of 0.22 (0.11, 0.37), and NAFLD occurred in 110 (18.8%) pregnant women. We observed a positive linear association between AIP and NAFLD (OR = 1.33, 95% CI: 1.19-1.48), which persisted after adjusting for potential confounders (OR = 1.2, 95% CI: 1.06-1.37). When AIP was used as a categorical variable, after adjusting for covariates, the NAFLD risk was significantly higher in the highest tertile of AIP than in the lowest group (OR = 2.02, 95% CI: 1.11-3.68). Their correlations were stable across subgroups and sensitivity analyses.Conclusion: In this secondary analysis of a prospective cohort study of pregnant Korean women, AIP was found to be positively associated with NAFLD. These outcomes might be used to screen for NAFLD in pregnant women.","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1511952"},"PeriodicalIF":4.0000,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825326/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fnut.2025.1511952","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Recent studies have shown an association between atherogenic index of plasma (AIP) and nonalcoholic fatty liver disease (NAFLD), but the association in a population of pregnant women remains unclear.

Objectives: Our study aimed to examine the association between AIP and NAFLD in pregnant Korean women.

Methods: Our study used publicly available data from Korea, which recruited singleton pregnant women between November 2014 and September 2016 who were at 10-14 weeks of gestation. The presence of NAFLD was diagnosed by liver ultrasound. AIP was calculated as log10 (TG/HDL). Participants were grouped according to AIP tertile: T1 (< 0.16, n = 195), T2 (0.16-0.32, n = 195), and T3 (>0.32, n = 196). Logistic regression models were used to estimate the relationship between AIP and NAFLD. Subgroup and sensitivity analyses were conducted to explore the stability of this relationship. Restricted cubic spline (RCS) curve fitting was employed to investigate potential non-linear associations.

Results: After excluding data on missing variables, 586 singleton pregnant women were finally included. The subjects included in the study had an average AIP of 0.22 (0.11, 0.37), and NAFLD occurred in 110 (18.8%) pregnant women. We observed a positive linear association between AIP and NAFLD (OR = 1.33, 95% CI: 1.19-1.48), which persisted after adjusting for potential confounders (OR = 1.2, 95% CI: 1.06-1.37). When AIP was used as a categorical variable, after adjusting for covariates, the NAFLD risk was significantly higher in the highest tertile of AIP than in the lowest group (OR = 2.02, 95% CI: 1.11-3.68). Their correlations were stable across subgroups and sensitivity analyses.

Conclusion: In this secondary analysis of a prospective cohort study of pregnant Korean women, AIP was found to be positively associated with NAFLD. These outcomes might be used to screen for NAFLD in pregnant women.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

韩国孕妇血浆动脉粥样硬化指数与非酒精性脂肪性肝病之间的关系：一项前瞻性队列研究的二次分析

背景：最近的研究表明血浆粥样硬化指数（AIP）与非酒精性脂肪性肝病（NAFLD）之间存在关联，但在孕妇群体中的关联尚不清楚。目的：本研究旨在探讨韩国孕妇AIP与NAFLD之间的关系。方法：我们的研究使用了来自韩国的公开数据，招募了2014年11月至2016年9月期间怀孕10-14 周的单胎孕妇。肝超声诊断为NAFLD。AIP计算为log10 （TG/HDL）。参与者根据AIP分类：T1 (< 0.16, n = 195),T2 （0.16-0.32, n = 195）和T3 （>0.32, n = 196）。采用Logistic回归模型估计AIP与NAFLD之间的关系。进行了亚组分析和敏感性分析，以探讨这种关系的稳定性。限制三次样条（RCS）曲线拟合用于研究潜在的非线性关联。结果：剔除缺失变量数据后，最终纳入586例单胎孕妇。纳入研究的受试者平均AIP为0.22(0.11,0.37)，110例（18.8%）孕妇发生NAFLD。我们观察到AIP和NAFLD之间呈正线性关联（OR = 1.33,95% CI: 1.19-1.48），在调整潜在混杂因素后，这种关系仍然存在（OR = 1.2,95% CI: 1.06-1.37）。当使用AIP作为分类变量时，在调整协变量后，AIP最高组的NAFLD风险显著高于最低组（OR = 2.02,95% CI: 1.11-3.68）。它们的相关性在亚组和敏感性分析中是稳定的。结论：在对韩国孕妇前瞻性队列研究的二级分析中，发现AIP与NAFLD呈正相关。这些结果可用于筛查孕妇NAFLD。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.