Huijia Liu , Jiaqi Zhang , Li Liu , Wenqing Li , Jing Yang , Peng Wang
{"title":"A sensitive fluorescent nanoprobe for sulfatase detection and imaging in living cells and in vivo†","authors":"Huijia Liu , Jiaqi Zhang , Li Liu , Wenqing Li , Jing Yang , Peng Wang","doi":"10.1039/d5cc00196j","DOIUrl":null,"url":null,"abstract":"<div><div>In this study, we developed a fluorescent probe TCF-SULF for sulfatase detection with satisfactory selectivity and sensitivity. After being encapsulated by the DSPE-PEG<sub>2000</sub>, the nanoprobe TCF-SULF NPs can be applied to imaging endogenous sulfatase in MCF-7 cells with low cytotoxicity. Importantly, TCF-SULF NPs were successfully used to monitor sulfatase <em>in vivo</em>.</div></div>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"61 22","pages":"Pages 4403-4406"},"PeriodicalIF":4.2000,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/cc/d5cc00196j?page=search","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1359734525003647","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
In this study, we developed a fluorescent probe TCF-SULF for sulfatase detection with satisfactory selectivity and sensitivity. After being encapsulated by the DSPE-PEG2000, the nanoprobe TCF-SULF NPs can be applied to imaging endogenous sulfatase in MCF-7 cells with low cytotoxicity. Importantly, TCF-SULF NPs were successfully used to monitor sulfatase in vivo.
期刊介绍：
ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
