Terapia farmacológica hipolipemiante para la reducción del riesgo cardiovascular en la diabetes. Visión clínica del Grupo de Trabajo de Enfermedad Cardiovascular de la Sociedad Española de Diabetes

Abstract

Patients with type 2 diabetes mellitus managed in both hospital and out-ofhospital settings usually have a high/very high cardiovascular risk, with a high burden of cardiovascular disease. All this justifies that the reduction of low-density lipoprotein cholesterol is the main therapeutic goal in diabetes. However, residual cardiovascular risk is very prevalent in type 2 diabetes, and is usually associated with atherogenic dyslipidemia and hyperlipoproteinemia(a); therefore, it is also necessary to reverse these lipoprotein abnormalities to achieve effective cardiovascular prevention. Given the considerable armamentarium of lipid-lowering drugs currently available, the Cardiovascular Disease Working Group of the Spanish Diabetes Society has considered it appropriate to carry out a narrative review and update of the effectiveness of these lipid-lowering drugs in the population with type 2 diabetes taking into account their effect on the lipoprotein profile and their potential impact on glycemic control.