Endocrinologia, Diabetes y Nutricion最新文献

{"title":"Hemorragia adrenal: serie de casos y actualización de manejo","authors":"María Carmen López García , Andrés Ruiz de Assin Valverde , Alejandro Sirvent Segovia , Cristina Lamas Oliveira , José Joaquín Alfaro Martínez","doi":"10.1016/j.endinu.2025.501579","DOIUrl":"10.1016/j.endinu.2025.501579","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 5","pages":"Article 501579"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valores de dinamometría absolutos y ajustados en pacientes con obesidad","authors":"Elena González Arnáiz , Juan José López Gómez , Diana Ariadel Cobo , Brisamar Estébanez , María García Duque , Carmen Dameto Pons , David Barajas Galindo , Diana García Sastre , Ana Urioste Fondo , María J. Cuevas , María D. Ballesteros Pomar","doi":"10.1016/j.endinu.2025.501560","DOIUrl":"10.1016/j.endinu.2025.501560","url":null,"abstract":"<div><h3>Background</h3><div>Hand grip strength — measured by dynamometry — is an essential tool in nutritional assessment, particularly for detecting sarcopenia, even before weight or muscle mass loss is evident. In individuals with obesity, hand grip strength can help identify muscle weakness that may not be apparent due to high body mass. The purpose of this study is to describe the absolute and adjusted hand grip strength values for weight, height, body mass index (BMI), and appendicular skeletal muscle mass (ASMM) in obese patients. It also aims to determine the prevalence of low muscle strength in this group of patients and to compare these results with those obtained in a healthy population.</div></div><div><h3>Material and Methods</h3><div>Prospective observational study including patients with obesity and healthy volunteers. Absolute and adjusted hand grip strength values for weight, height, BMI and appendicular muscle mass were determined in patients with obesity and compared with the results of healthy volunteers. Muscle strength was measured by hand grip strength according to Sánchez-Torralvo, Dodds, and <<!--> <!-->−2<!--> <!-->SD cut-off points of healthy reference population.</div></div><div><h3>Results</h3><div>The results obtained show that the absolute hand grip strength values are higher in healthy volunteers (30.7<!--> <!-->±<!--> <!-->10.5<!--> <!-->kg) vs patients with obesity (26.6<!--> <!-->±<!--> <!-->9.7<!--> <!-->kg); <em>P</em> <!--><<!--> <!-->.008. As for hand grip strength values adjusted for height, weight, BMI and ASMM, they are also statistically significantly higher in healthy volunteers (18.0<!--> <!-->±<!--> <!-->5.5 vs. 15.9<!--> <!-->±<!--> <!-->5.4, <em>P</em> <!--><<!--> <!-->.014; 05<!--> <!-->±<!--> <!-->0.10 vs. 0.2<!--> <!-->±<!--> <!-->0.06, <em>P</em> <!--><<!--> <!-->.001; 1.4<!--> <!-->±<!--> <!-->0.4 vs. 0.6<!--> <!-->±<!--> <!-->0.2, <em>P</em> <!--><<!--> <!-->.001; 1.5<!--> <!-->±<!--> <!-->0.2 vs. 0.9<!--> <!-->±<!--> <!-->0.3, <em>P</em> <!--><<!--> <!-->.001). According to sex, men had significantly higher absolute and adjusted hand grip strength values in both obese patients and healthy volunteers. The prevalence of low muscle strength in patients with obesity goes from 14.5% up and 23.4% depending on the cut-off points used, being higher with those of Sánchez-Torralvo's cut-off points. Based on sex distribution, obese men had a higher prevalence of low muscle strength with absolute hand grip strength values vs women, being these differences statistically significant only with the Sánchez-Torralvo's cut-off points. In terms of the prevalence of low muscle strength with adjusted hand grip strength values, more variable percentages (3.2%-96.8%) were observed without clear differences across sexes.</div></div><div><h3>Conclusions</h3><div>Hand grip strength values in obese patients vary according to absolute or adjusted measurements. Obese patients have lower absolute and adj","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 5","pages":"Article 501560"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteogénesis imperfecta tipo V: a propósito de un caso clínico","authors":"María Fernanda Reinoso Gomezcoello ,&nbsp;Isabel Pavón de Paz ,&nbsp;Cristina Navea Aguilera ,&nbsp;Belén Gil Fournier ,&nbsp;Ana María Bueno Sanchez ,&nbsp;Guadalupe Guijarro de Armas ,&nbsp;María Merino Viveros ,&nbsp;Jose Antonio Rosado Sierra ,&nbsp;Paloma Iglesias Bolaños ,&nbsp;María Durán Martínez","doi":"10.1016/j.endinu.2025.501544","DOIUrl":"10.1016/j.endinu.2025.501544","url":null,"abstract":"<div><div>Osteogenesis imperfecta (OI) is a rare inherited connective tissue disorder. It is characterized by short stature, fragility and decreased bone mass, which leads to multiple and recurrent fractures after low-energy trauma, which generates susceptibility to long bone deformity and vertebral compression. There are several types of OI, with types<!--> <!-->I to<!--> <!-->IV, in which the <em>COL1A1</em> and <em>COL1A2</em> genes are affected, being the most frequent. In recent years, the discovery of new forms of OI has led to research into the pathways critical aspects of bone metabolism, with new genes involved being identified. The mutation in <em>IFITM5</em> has been identified as the cause of OI type<!--> <!-->V, of autosomal dominant inheritance. OI type<!--> <!-->V has distinctive clinical features including the developmentt of hypertrophic callus after fracture, early calcification of the interosseous membrane in the forearm, and the presence of hyperdense metaphyseal bands.</div><div>The case of a patient with a novo mutation in <em>IFITM5</em> is presented.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 5","pages":"Article 501544"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of glucagon-like peptide-1 receptor agonists on the risk of major adverse limb events in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized clinical trials","authors":"Fernando Garagoli ,&nbsp;Walter Masson ,&nbsp;Leandro Barbagelata ,&nbsp;Martín Lobo","doi":"10.1016/j.endinu.2025.501562","DOIUrl":"10.1016/j.endinu.2025.501562","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effect of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on the risk of major adverse limb events (MALE).</div></div><div><h3>Methods</h3><div>We conducted a systematic review and meta-analysis of randomized clinical trials assessing the effects of GLP-1RAs therapy on peripheral arterial disease (PAD)-related outcomes in patients with type 2 diabetes mellitus (T2DM). This meta-analysis was performed according to PRISMA guidelines. The random-effects model was performed.</div></div><div><h3>Results</h3><div>A total of 6 randomized clinical trials were considered eligible for this systematic review. On the other hand, 4 clinical trials were included for the meta-analysis. A total of 15,427 subjects were allocated to the GLP-1RAs group, and 15,476 to the placebo group. Overall, this meta-analysis showed that the use of GLP-1RAs is associated with a lower risk of PAD-related events (OR, 0.78; 95%CI, 0.62–0.98, <em>I</em>² <!-->=<!--> <!-->39%) vs the placebo group. The analytical evaluation did not suggest publication bias, and the sensitivity analysis demonstrated that the result was robust.</div></div><div><h3>Conclusion</h3><div>This meta-analysis demonstrated that the use of GLP-1RAs is associated with fewer PAD-related clinical events. Of note, despite the clinical significance of PAD, most analyzed studies did not specifically report on these events. Future studies should include PAD as a key endpoint. PROSPERO Registration: CRD42024565567.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 5","pages":"Article 501562"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estudio de la mutación C228T del promotor de TERT en punciones aspirativas tiroideas de la categoría IV de la clasificación de Bethesda","authors":"Berta Bella Burgos ,&nbsp;Ruben Carrera Salas ,&nbsp;Ricard Onieva Carbajo ,&nbsp;Catalina Padilla Navas ,&nbsp;María del Carmen Ramos Guijo ,&nbsp;Laura Escudero Larrá ,&nbsp;Rosa María Rodríguez Millán ,&nbsp;José Antonio Vázquez Luque ,&nbsp;Silvia Hurtado Mas ,&nbsp;Adrià Asensi Puig ,&nbsp;Carmen María Blázquez Mañá ,&nbsp;Santi Barcons Vilaplana ,&nbsp;Ismail Capel Flores ,&nbsp;Xavier Guirao Garriga ,&nbsp;Víctor Pérez-Riverola ,&nbsp;Mario Prenafeta Moreno ,&nbsp;Neus Combalia Soriano ,&nbsp;Ruth Orellana Fernández ,&nbsp;Joan Carles Ferreres Piñas ,&nbsp;María Rosa Bella-Cueto","doi":"10.1016/j.endinu.2025.501564","DOIUrl":"10.1016/j.endinu.2025.501564","url":null,"abstract":"<div><h3>Introduction</h3><div>Since the C228T mutation in the <em>TERT</em> promoter (<em>TERTp</em>) has been identified almost exclusively in thyroid malignancies, our objective was to study the usefulness of its determination in thyroid fine needle aspirations (FNA) of the IV category of the Bethesda classification (B.IV).</div></div><div><h3>Methodology</h3><div>From the FNAs performed between 1993 and 2015, we selected those with a diagnosis of B.IV or equivalent and subsequent thyroidectomy. A retrospective study of the C228T mutation in <em>TERTp</em> was performed by pyrosequencing in neoplastic cases (adenomas, low risk neoplasms and carcinomas), both from the surgical specimen and from the FNA material if feasible.</div></div><div><h3>Results</h3><div>79 cases with a diagnosis of B.IV were identified, and mutational study was performed in the 61 cases corresponding to neoplasms, identifying 10 cases with the mutation (12.6% of the series), with a higher presence in Poorly Differentiated Carcinomas (PDC) or with a minor PDC component (45%), in cases with death attributable to thyroid carcinoma (50%) and in patients alive but with persistence of thyroid carcinoma (50%). The mutation was confirmed in 7 of 8 cases with the mutation and satisfactory cytological material. In 4 cases, preoperative knowledge of the mutation could have avoided a two-stage thyroidectomy.</div></div><div><h3>Conclusion</h3><div>The study of the C228T mutation of <em>TERTp</em> can be useful to detect malignancy and establish the best surgical approach in patients with thyroid FNA with a diagnosis of B.IV.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 5","pages":"Article 501564"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mujeres trans y cis en el deporte: citius, altius, fortius, sed aequitas","authors":"Óscar Moreno-Perez ,&nbsp;Inés Modrego-Pardo","doi":"10.1016/j.endinu.2025.501547","DOIUrl":"10.1016/j.endinu.2025.501547","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 4","pages":"Article 501547"},"PeriodicalIF":0.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New drugs in pituitary diseases","authors":"Fernando Cordido ,&nbsp;Pedro Iglesias","doi":"10.1016/j.endinu.2025.501546","DOIUrl":"10.1016/j.endinu.2025.501546","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 3","pages":"Article 501546"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addendum a «La importancia de la técnica MLPA en el diagnóstico de la neoplasia endocrina múltiple tipo 1», Endocrinología, Diabetes y Nutrición 71 (2024) 221-225","authors":"Antonio Bustos-Merlo,&nbsp;Carlos Javier García Calvente,&nbsp;Antonio Rosales-Castillo","doi":"10.1016/j.endinu.2025.01.001","DOIUrl":"10.1016/j.endinu.2025.01.001","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 3","pages":"Article 101540"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical development of hypopituitarism due to septic embolism: A case report","authors":"Jordi Tortosa-Carreres ,&nbsp;Lorena Hernández-Rienda ,&nbsp;Susana Tenés-Rodrigo ,&nbsp;Amparo Alba-Redondo ,&nbsp;María Luisa Martínez-Triguero","doi":"10.1016/j.endinu.2024.09.005","DOIUrl":"10.1016/j.endinu.2024.09.005","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 3","pages":"Article 101529"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estudio de la altura de las células en el subtipo de célula alta del carcinoma papilar de tiroides. ¿Es un factor clave en el pronóstico?","authors":"Ricard Onieva Carbajo ,&nbsp;Joan Carles Ferreres Piñas ,&nbsp;Flavia Alberto ,&nbsp;Ismael Capel Flores ,&nbsp;Martina Pérez ,&nbsp;María Rosa Bella Cueto","doi":"10.1016/j.endinu.2024.09.006","DOIUrl":"10.1016/j.endinu.2024.09.006","url":null,"abstract":"<div><h3>Introduction</h3><div>The tall cell subtype of papillary thyroid carcinoma (PTC) is considered to have poor prognosis, but its diagnostic criteria have been modified on several occasions. The aim of our study was to find the best diagnostic criteria to relate the tall cell subtype with aggressiveness and poor prognosis.</div></div><div><h3>Material and methods</h3><div>In 171 cases of classic subtype and tall cell subtype of PTC, the percentage of cells between two and three times taller than wide (C2-3) and cells more than three times taller than wide (Cx3) was determined by two observers, after obtaining reference images. Groups were made based on the percentage of cells of each component (&lt;2%, between 2 and 10%, between 11 and 30%, between 31 and 50% and &gt;<!--> <!-->50%) and were correlated with clinical and histopathological data. Interobserver agreement was also assessed.</div></div><div><h3>Results</h3><div>According to the current WHO classification criteria, only 8 cases (5%) of tall cell subtype were identified. The comparison of the risk of recurrence at 5 years based on the percentage and type of cells showed that it increased significantly from &gt;<!--> <!-->10% of the Cx3 cell component, while there were no significant differences in recurrence rate with any C2-3 cell percentages. Very good interobserver agreement was obtained (Kappa index: 0.83).</div></div><div><h3>Conclusions</h3><div>We consider relevant reporting the presence of Cx3 cells from 10% in PTC as it is associated with a significant increase in the recurrence rate at 5 years. Interobserver agreement is very good if reference images are available.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 3","pages":"Article 101530"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}