Endocrinologia, Diabetes y Nutricion最新文献

英文中文

Tiroides y reproducción asistida 甲状腺和辅助生殖

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-11-19 DOI: 10.1016/j.endinu.2024.10.001

Gemma Sesmilo

引用次数: 0

Association between the rs12654778 SNP of the β-2 adrenergic receptor and LDL cholesterol levels in the Chilean adult population 智利成年人群中 β-2 肾上腺素能受体 rs12654778 SNP 与低密度脂蛋白胆固醇水平之间的关系

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-09 DOI: 10.1016/j.endinu.2024.06.005

Carlos González-Contreras , Miquel Martorell , Natalia Ulloa , Carolina Ochoa-Rosales , Felipe Díaz-Toro , Fanny Petermann-Rocha , Carlos Celis-Morales , Marcelo Villagran , Lorena Mardones , on behalf of the ELHOC Group (Epidemiology of Lifestyle and Health Outcomes in Chile)

Introduction

Various polymorphisms in the beta-2 adrenergic receptor (ADRB2) gene have been associated with cardiometabolic risk factors, such as hypertension, dyslipidemia, type 2 diabetes mellitus and obesity contributing to the physiopathology of these chronic conditions. However, the association of the single nucleotide polymorphism (SNP) rs12654778 at the ADRB2 gene with metabolic changes has been poorly studied and there is no information on the Chilean adult population.

Objective

To investigate the association between the rs12654778 SNP at the ADRB2 gene with cardiometabolic risk markers in a Chilean adult population.

Methods

We conducted a cross-sectional study including 404 participants from the GENADIO study whom were genotyped for rs12654778 and categorized into GG, AG, and AA genotypes. Associations with cardiometabolic risk markers, such as blood pressure, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, blood glucose and insulin were examined using multivariate regression analysis, while statistical models were adjusted for sociodemographic and lifestyle variables.

Results

Our findings indicate a significant association between the presence of the protective genotype (AA) of the rs12654778 polymorphism and lower low-density lipoprotein cholesterol levels corresponding to 8.75 mg/dL per each copy of the protective allele (maximally adjusted model). No significant associations were seen for the remaining variables.

Conclusion

The AA genotype of the rs12654778 SNP at the ADRB2 gene had a protective effect specifically against low-density lipoprotein cholesterol levels. This is the first study ever conducted in Chile on this SNP of ADRB2 and one of the few conducted worldwide to establish an association between the rs12654778 SNP at the ADRB2 gene and LDL cholesterol.

导言：β-2 肾上腺素能受体（ADRB2）基因中的多种多态性与高血压、血脂异常、2 型糖尿病和肥胖等心脏代谢风险因素有关，而这些因素是这些慢性疾病的生理病理因素。然而，关于 ADRB2 基因的单核苷酸多态性（SNP）rs12654778 与代谢变化之间的关系的研究却很少，而且也没有关于智利成年人群的信息。方法我们进行了一项横断面研究，纳入了 404 名来自 GENADIO 研究的参与者，对他们进行了 rs12654778 基因分型，并将其分为 GG、AG 和 AA 基因型。研究人员使用多变量回归分析检验了这些基因与血压、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、血糖和胰岛素等心脏代谢风险指标之间的关系，并根据社会人口学变量和生活方式变量对统计模型进行了调整。结果我们的研究结果表明，rs12654778 多态性的保护性基因型（AA）的存在与较低的低密度脂蛋白胆固醇水平之间存在显著的关联，每一个保护性等位基因拷贝对应 8.75 毫克/分升的低密度脂蛋白胆固醇水平（最大调整模型）。结论 ADRB2 基因中 rs12654778 SNP 的 AA 基因型对低密度脂蛋白胆固醇水平具有保护作用。这是智利首次对 ADRB2 基因的 SNP 进行研究，也是全球为数不多的在 ADRB2 基因的 rs12654778 SNP 与低密度脂蛋白胆固醇之间建立联系的研究之一。

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引用次数: 0

Association between the economic situation and diabetes mellitus, metabolic control and the use of health services in a Spanish region 西班牙某地区经济状况与糖尿病、代谢控制和医疗服务使用之间的关系

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-05 DOI: 10.1016/j.endinu.2024.08.004

Roberto Sánchez Medina , Alejandro de Arriba Fernández , Ángela Gutiérrez Pérez , José Luis Alonso Bilbao

Introduction

The prevalence of diabetes mellitus (DM) has increased in low- and middle-income countries and in marginal areas of developed countries_. In Spain, it grew by 3.42% from 1993 to 2020. In the Canary Islands, the increase was even greater.

Objectives

The main one was to evaluate the possible relationship of the income level with DM, different markers of metabolic control and the use of Primary Care services, in Las Palmas de Gran Canaria (LPGC). Secondary ones are to determine the prevalence of DM in the city of LPGC, to describe the sociodemographic characteristics, the use of Primary Care services of the population with DM, the level of registry of variables related to metabolic control and the main process indicators and intermediate results of the metabolic control in the population with DM in the city of LPGC.

Material and method

All patients with DM over 14 years of age, living in LPGC as of 12/31/22 were included. Data were collected from the electronic medical records of the Canarian Primary Care Service, the National Institute of Statistics and the National Tax Agency.

Results and conclusion

The overall prevalence of DM was 11.39%. The mean age of participants was 67.06 years (SD = 13.86), lower in men than in women. The groups with low or moderate income accounted for more than 40% of the prevalence each, while those with high income barely accounted for 10%. Higher income levels corresponded to lower use of health resources and registration of metabolic variables, while decreasing income levels were associated to higher prevalence of overweight/obesity, worse lipid and glycemic profiles and higher risk of diabetic foot. The middle-income group showed the highest prevalence of pathological/uncertain diabetic retinopathy, lower glomerular filtration and higher LDL levels.

导言在中低收入国家和发达国家的边缘地区，糖尿病（DM）的发病率有所上升。从 1993 年到 2020 年，西班牙的发病率增长了 3.42%。在拉斯帕尔马斯-德-大加那利岛（LPGC），主要目的是评估收入水平与糖尿病、代谢控制的不同指标以及初级保健服务的使用之间可能存在的关系。其次是确定大加那利岛拉斯帕尔马斯市的糖尿病发病率，描述社会人口特征、糖尿病患者使用初级保健服务的情况、与代谢控制相关的变量的登记水平以及大加那利岛拉斯帕尔马斯市糖尿病患者代谢控制的主要过程指标和中间结果。数据收集自加那利初级保健服务机构、国家统计局和国家税务局的电子病历。参与者的平均年龄为 67.06 岁（SD = 13.86），男性低于女性。低收入或中等收入群体的患病率均超过 40%，而高收入群体仅占 10%。收入水平越高，医疗资源使用率和代谢变量登记率越低，而收入水平越低，超重/肥胖发生率越高，血脂和血糖状况越差，患糖尿病足的风险越高。中等收入组的病理/不确定糖尿病视网膜病变发病率最高，肾小球滤过率较低，低密度脂蛋白水平较高。

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引用次数: 0

DIABETES MELLITUS (PÓSTERES) 糖尿病（Pósteres）

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/S2530-0164(24)00186-1

引用次数: 0

METABOLISMO ÓSEO Y FOSFOCÁLCICO (COMUNICACIONES ORALES) 骨与磷钙代谢（口头交流）

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/S2530-0164(24)00180-0

引用次数: 0

Prevalence of hypogonadism in men with and without chronic obstructive pulmonary disease: A cross-sectional study 患有和未患有慢性阻塞性肺病的男性性腺功能减退症的患病率：横断面研究

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/j.endinu.2024.05.010

Horacio Matías Castro , Pablo Knoblovits , Joaquin Maritano Furcada , Eduardo Luis De Vito , Sebastían Matias Suarez , Pablo Rene Costanzo

Background

Hypogonadism is a common finding of chronic obstructive pulmonary disease (COPD). However, the prevalence of hypogonadism in COPD varies among studies. The aim of this study was to determine and compare the prevalence of hypogonadism in men with and without COPD.

Methods

We conducted a cross-sectional study with 134 patients with stable COPD and 70 age-matched men with non-COPD. Hypogonadism was defined by the presence of symptoms according to the Androgen Deficiency in Aging Males questionnaire, along with total testosterone deficiency (<300 ng/dL).

Results

Patients had a mean age of 68 years (SD, 6), a body mass index of 28 kg/m² (SD, 6), and 17% were current smokers. The prevalence of hypogonadism was 41.8% in COPD men (N = 56, 95%CI, 33–51) and 10.0% in non-COPD men (N = 7, 95%CI, 4–20), with a prevalence ratio of 4.2 (95%CI, 2.0–8.7, p < 0.001). The prevalence of low total testosterone concentrations (<300 ng/dL) were significantly higher in COPD patients vs the control group (47.0% vs 15.7%, p = <0.001). In the COPD group, 89.3% of patients had hypogonadotropic hypogonadism and 10.7%, hypergonadotropic hypogonadism. The prevalence of hypogonadism was higher in severe vs non-severe COPD patients (55.8% vs 35.2%; p = 0.024).

Conclusions

The prevalence of hypogonadism was high and greater in COPD vs non-COPD men. This study suggests that COPD patients should be screened for hypogonadism.

背景性腺功能减退症是慢性阻塞性肺病（COPD）的常见病因。然而，慢性阻塞性肺病患者性腺功能减退症的发病率在不同研究中存在差异。本研究的目的是确定并比较慢性阻塞性肺病男性和非慢性阻塞性肺病男性性腺功能减退症的患病率。方法我们对 134 名稳定期慢性阻塞性肺病患者和 70 名年龄匹配的非慢性阻塞性肺病男性进行了横断面研究。结果患者的平均年龄为 68 岁（SD，6），体重指数为 28 kg/m2（SD，6），17% 的患者目前吸烟。慢性阻塞性肺病男性的性腺功能减退症患病率为41.8%（N = 56，95%CI，33-51），非慢性阻塞性肺病男性的患病率为10.0%（N = 7，95%CI，4-20），患病率比为4.2（95%CI，2.0-8.7，p <0.001）。与对照组相比，慢性阻塞性肺病患者总睾酮浓度低（300 ng/dL）的患病率明显更高（47.0% vs 15.7%，p = 0.001）。在 COPD 组中，89.3% 的患者患有性腺功能减退症，10.7% 的患者患有高性腺功能减退症。严重慢性阻塞性肺病患者与非严重慢性阻塞性肺病患者相比，性腺功能减退症的患病率更高（55.8% vs 35.2%; p = 0.024）。这项研究表明，慢性阻塞性肺病患者应接受性腺功能减退症筛查。

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引用次数: 0

OBESIDAD (COMUNICACIONES ORALES) 肥胖症（口头交流）

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/S2530-0164(24)00177-0

引用次数: 0

ENDOCRINOLOGÍA BÁSICA Y TRASLACIONAL (PÓSTERES) 基础与转化内分泌学（海报）

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/S2530-0164(24)00182-4

引用次数: 0

SUPRARRENALES (COMUNICACIONES ORALES) 肾上腺（口头交流）

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/S2530-0164(24)00173-3

引用次数: 0

NEUROENDOCRINOLOGÍA (COMUNICACIONES ORALES) 神经内分泌学（口头交流）

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion

Pub Date : 2024-10-01 DOI: 10.1016/S2530-0164(24)00172-1

引用次数: 0

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