A novel hierarchical porous sheets of bimetallic terephthalate frameworks for the efficient detection of theophylline drug

Abstract

A novel Cerium – Magnesium terephthalate frameworks (Ce-Mg TPFs) was synthesized by facile hydrothermal method and characterized by microscopic and spectroscopic techniques. Subsequently, Ce-Mg TPFs was casted on the glassy carbon electrode (Ce-Mg TPFs/GCE) for the amperometric sensing of the theophylline (TPH), a drug for treating various respiratory diseases. The electrochemical experiments were performed with Britton-Robinson (B-R) buffer solutions (pH 4.0) for irreversible electro-oxidation of TPH. The modified sensor shows greater stability, selectivity, reproducibility with low limit of detection (LOD) and limit of quantification (LOQ) of 0.07 µmol L⁻¹ and 0.25 µmol L⁻¹, respectively with the linear range of 1.0 × 10⁻⁶ to 1.50 × 10⁻⁴ mol L⁻¹ and sensor mechanism was found to be diffusion-controlled phenomena. The proposed sensor offers a promising approach to monitor TPH levels in real-time (synthetic urine samples, TPH tablets and syrup solutions), allowing healthcare providers to adjust dosages and prevent toxicity.