Investigation of PLA/ZnO nanofibers for piezoelectric and nerve regeneration applications

IF 4.1 3区工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Sensors and Actuators A-physical Pub Date : 2025-02-17 DOI:10.1016/j.sna.2025.116340

Meysam Moezzi , Meghdad Kamali Moghaddam , Jafar Rahimzadeh , Marzieh Ranjbar-Mohammadi , Fred Barez

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Abstract

This study examines the preparation and characterization of poly(L-lactic acid) (PLA) and zinc oxide (ZnO) composite nanofibrous mats with ZnO concentrations of 0, 1, 5, and 10 wt% produced via electrospinning. The effects of varying ZnO concentrations on the properties of PLA nanofibrous mats are investigated for potential applications in biomedical wireless electrical stimulators. Scanning electron microscopy confirms successful nanofiber production, with significant variations in fiber diameters based on ZnO content; the average diameter decreases with increasing ZnO concentration, especially in PLA-ZnO 10 % nanofibers. ZnO nanoparticles enhances the mechanical strength and stiffness of the scaffolds, as shown by increased ultimate stress and modulus values, while ultimate and locking strain values decrease. Electromechanical tests indicate that higher ZnO concentrations improve piezoelectric performance, with PLA-ZnO 5 % scaffolds showing optimal characteristics for nerve regeneration applications due to their balance of biocompatibility and electrical output. Biological assessments with PC12 cells reveal that up to 5 wt% of ZnO nanoparticles promote a favorable environment for nerve cell proliferation.

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本研究探讨了通过电纺丝法制备聚乳酸（PLA）和氧化锌（ZnO）复合纳米纤维垫（氧化锌浓度分别为 0、1、5 和 10 wt%）的过程及其特性。研究了不同氧化锌浓度对聚乳酸纳米纤维垫性能的影响，以探讨其在生物医学无线电刺激器中的潜在应用。扫描电子显微镜证实了纳米纤维的成功生产，根据氧化锌含量的不同，纤维直径也有显著变化；平均直径随着氧化锌浓度的增加而减小，尤其是在聚乳酸-氧化锌含量为 10% 的纳米纤维中。ZnO 纳米粒子提高了支架的机械强度和刚度，表现为极限应力和模量值增加，而极限应变和锁定应变值降低。机电测试表明，氧化锌浓度越高，压电性能越好，聚乳酸-氧化锌 5 % 支架由于兼顾了生物相容性和电输出，在神经再生应用中显示出最佳特性。用 PC12 细胞进行的生物学评估显示，高达 5 wt% 的氧化锌纳米颗粒可为神经细胞增殖创造有利环境。

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来源期刊

Sensors and Actuators A-physical 工程技术-工程：电子与电气

CiteScore

8.10

自引率

6.50%

发文量

630

审稿时长

49 days

期刊介绍： Sensors and Actuators A: Physical brings together multidisciplinary interests in one journal entirely devoted to disseminating information on all aspects of research and development of solid-state devices for transducing physical signals. Sensors and Actuators A: Physical regularly publishes original papers, letters to the Editors and from time to time invited review articles within the following device areas: • Fundamentals and Physics, such as: classification of effects, physical effects, measurement theory, modelling of sensors, measurement standards, measurement errors, units and constants, time and frequency measurement. Modeling papers should bring new modeling techniques to the field and be supported by experimental results. • Materials and their Processing, such as: piezoelectric materials, polymers, metal oxides, III-V and II-VI semiconductors, thick and thin films, optical glass fibres, amorphous, polycrystalline and monocrystalline silicon. • Optoelectronic sensors, such as: photovoltaic diodes, photoconductors, photodiodes, phototransistors, positron-sensitive photodetectors, optoisolators, photodiode arrays, charge-coupled devices, light-emitting diodes, injection lasers and liquid-crystal displays. • Mechanical sensors, such as: metallic, thin-film and semiconductor strain gauges, diffused silicon pressure sensors, silicon accelerometers, solid-state displacement transducers, piezo junction devices, piezoelectric field-effect transducers (PiFETs), tunnel-diode strain sensors, surface acoustic wave devices, silicon micromechanical switches, solid-state flow meters and electronic flow controllers. Etc...