Exploring the anti-diabetic properties of camel milk: effects on blood glucose, antioxidant defense, and organ histo-morphological features in rabbits

Abstract

Camel milk (CM) has acquired substantial consideration in contemporary years owing to its potential prospective pharmaceutical benefits besides nutritional properties. As, CM retain inimitable composition and attain sophisticated concentration of bioactive compounds, thus helps in regulation of blood glucose level, and improves insulin sensitivity. Contemporary study intends to explore anti-diabetic inflictions of CM, besides body weight, blood profile, antioxidant defense and organ integrity in diabetic rabbits. To achieve this, a total of 36 rabbits was randomly alienated into six equal groups (N = 6), such as control, control + camel milk, diabetic control, insulin treated, camel milk treated, and CM + insulin. Diabetes was induced by injecting STZ (50-mg/kg). The diabetic rabbits were treated either with CM (100 ml/rabbit/day), or insulin (6 unit/kg/day) and their combination (CM-30 ml + insulin 3-unit/day) for 42 days. Body weight, blood glucose level and hematological indices were measured weekly. Reduced body weight, elevated blood glucose level and altered hematological indices were noticed in diabetes induced rabbits. On the contrary, improved weight gain, glycemic level, anti-oxidant defense and blood chemistry were noticed in groups treated with camel milk individually and insulin; conversely, non-significant changes were seen in CM + insulin treated group. Diabetic control group revealed gross-pathological changes in liver, kidney, intestine and pancreas. CM and insulin augmented organ integrity and stability. Convincingly, these outcomes strongly indicate therapeutic potential of CM that regulated hyperglycemic condition and mitigated the negative impact of diabetes in organ histomorphology.