Hippocampal Subfield Abnormalities in Patients With Primary Trigeminal Neuralgia

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY Journal of Neuroimaging Pub Date : 2025-02-18 DOI:10.1111/jon.70026

Elena Filimonova, Anton Pashkov, Galina Moysak, Azniv Martirosyan, Jamil Rzaev

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Abstract

Background and Purpose

Primary trigeminal neuralgia (PTN) is a prevalent chronic pain disorder whose pathogenesis is not solely confined to the trigeminal system. Although substantial progress has been made in understanding the underlying mechanisms, comprehensive and consistent data concerning the involvement of the hippocampal formation in this process are lacking. The aim of this study was to evaluate structural changes in hippocampal subfields in patients with PTN.

Methods

Fifty-nine individuals who were diagnosed with PTN and 28 healthy controls matched for age and sex underwent high-resolution 3 Tesla MRI. HippUnfold software was used for the segmentation of hippocampal subfields and the extraction of features. Covariance analyses were performed to analyze changes in the volume, thickness, and gyrification index of different subfields in patients with PTN compared to controls. Furthermore, the relationships between MR morphometry data and the severity of nerve root compression, as well as the intensity and duration of pain, were examined in patients with PTN.

Results

Our analysis demonstrated a decrease in the volume of the right cornu ammonis subfield 1 (CA1)–CA3 and left CA2 hippocampal subfields in patients with PTN compared to healthy controls (adjusted p < 0.05 for all comparisons). No statistically significant associations were found between hippocampal MR morphometry data and clinical metrics.

Conclusions

Our results suggest the existence of bilateral structural abnormalities in the hippocampal subfields in individuals with PTN, which could contribute to the development and progression of this condition.

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来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!