Comparison of Survival After Treatment of Presumed Intracranial Meningioma by Radiotherapy or Surgery in 285 Dogs

IF 2.2 2区农林科学 Q1 VETERINARY SCIENCES Journal of Veterinary Internal Medicine Pub Date : 2025-02-19 DOI:10.1111/jvim.70011

Rachel Geiger, Joe Mankin, Holger A. Volk, Steven de Decker, Nate van Asselt, Karanbir Randhawa, Tara Ehling, Charles A. Maitz, Ada Naramor, Joan R. Coates, Catherine Stalin, Lauren Johnstone, Joanna Morris, Ioannis N. Plessas, Alexander Forward, Laurent Garosi, Elena Scarpante, Giunio Cherubini, Tom Harcourt-Brown, Sheila Carrera-Justiz, Jishnu Rao Gutti, Marilia Takada, Joel White, Koichi Nagata, Marc Kent, Renee Barber, Daisuke Ito, Tomohiro Nakayama, Ayaka Oshima, Naoki Sekigucki, Lauren Smith-Oskrochi, Nick Jeffery

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Abstract

Background

The comparative effectiveness of radiotherapy and surgery for treating intracranial meningioma is unknown.

Objectives

To compare survival after treatment of suspected intracranial meningioma by either surgery or radiotherapy.

Animals

Two hundred eighty-five companion dogs with suspected intracranial meningiomas presenting to 11 specialty clinics in three countries.

Methods

Parallel cohort comparison study on retrospective data. Dogs diagnosed with intracranial meningioma by board-certified veterinary neurologists or radiologists and treated by radiotherapy or surgery were identified through medical record searches and presenting and survival data extracted. Lesion site was classified as rostro- or caudotentorial and size was measured on contrast magnetic resonance images. Outcome was all-cause death. Analysis of survival by Cox proportional hazards, including selection for optimal multivariable model using lasso, counterfactual modeling including variables associated with treatment allocation and survival.

Results

One hundred sixty-eight dogs received radiotherapy and 117 received surgery. All analyses indicated reduced survival associated with surgery compared to radiotherapy. There was a median survival after surgery of 297 (IQR: 99–768) days compared with 696 (IQR: 368–999) for dogs treated by radiation, associated with a univariable hazard ratio of 1.802 (95% CI: 1.357–2.394). Counterfactual modeling estimated a mean survival of 480 (95% CI: 395–564) days after surgery and 673 (95% CI: 565–782) days after radiotherapy, representing a decrease in survival of 29%. Location and size of the lesion were not associated with survival duration.

Conclusions and Clinical Importance

Dogs with suspected intracranial meningioma have substantially superior survival after radiotherapy compared to surgery.

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285只犬颅内脑膜瘤放疗与手术后生存率比较

背景放疗与手术治疗颅内脑膜瘤的比较效果尚不清楚。目的比较疑似颅内脑膜瘤手术与放疗的生存率。动物285只疑似颅内脑膜瘤的伴侣犬出现在三个国家的11个专科诊所。方法采用回顾性平行队列比较研究。经委员会认证的兽医神经科医生或放射科医生诊断为颅内脑膜瘤并接受放疗或手术治疗的狗通过医疗记录搜索和提取的表现和生存数据来确定。病变部位分为后脑区或尾幕区，并通过磁共振成像测量病变大小。结果是全因死亡。通过Cox比例风险分析生存率，包括使用套索选择最佳多变量模型，包括与治疗分配和生存率相关的变量的反事实建模。结果放疗犬168只，手术犬117只。所有分析表明，与放疗相比，手术降低了生存率。术后犬的中位生存期为297天（IQR: 99-768），而放疗犬的中位生存期为696天（IQR: 368-999），单变量风险比为1.802 （95% CI: 1.357-2.394）。反事实模型估计手术后平均生存期为480天（95% CI: 395-564），放疗后平均生存期为673天（95% CI: 565-782），生存率下降29%。病变的位置和大小与生存时间无关。结论及临床意义疑似颅内脑膜瘤犬放疗后生存率明显优于手术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Veterinary Internal Medicine 农林科学-兽医学

CiteScore

4.50

自引率

11.50%

发文量

243

审稿时长

22 weeks

期刊介绍： The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.