Material Design, Fabrication Strategies, and the Development of Multifunctional Hydrogel Composites Dressings for Skin Wound Management

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomacromolecules Pub Date : 2025-03-10 Epub Date: 2025-02-17 DOI:10.1021/acs.biomac.4c01715

Ziteng Wu , Dongdong Lu , Shuo Sun , Manqi Cai , Lin Lin , Mingning Zhu

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Abstract

The skin is fragile, making it very vulnerable to damage and injury. Untreated skin wounds can pose a serious threat to human health. Three-dimensional polymer network hydrogels have broad application prospects in skin wound dressings due to their unique properties and structure. The therapeutic effect of traditional hydrogels is limited, while multifunctional composite hydrogels show greater potential. Multifunctional hydrogels can regulate wound moisture through formula adjustment. Moreover, hydrogels can be combined with bioactive ingredients to improve their performance in wound healing applications. Stimulus-responsive hydrogels can respond specifically to the wound environment and meet the needs of different wound healing stages. This review summarizes the material types, structure, properties, design considerations, and formulation strategies for multifunctional hydrogel composite dressings used in wound healing. We discuss various types of recently developed hydrogel dressings, highlights the importance of tailoring their physicochemical properties, and addresses potential challenges in preparing multifunctional hydrogel wound dressings.

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用于皮肤伤口处理的多功能水凝胶复合敷料的材料设计、制造策略和发展。

皮肤很脆弱，很容易受到伤害。未经治疗的皮肤伤口会对人体健康构成严重威胁。三维聚合物网络水凝胶以其独特的性质和结构在皮肤创面敷料中有着广阔的应用前景。传统的水凝胶治疗效果有限，而多功能复合水凝胶显示出更大的潜力。多功能水凝胶可通过配方调整调节伤口水分。此外，水凝胶可以与生物活性成分结合，以提高其在伤口愈合应用中的性能。刺激反应型水凝胶能够对创面环境做出特异性反应，满足不同创面愈合阶段的需要。本文综述了用于伤口愈合的多功能水凝胶复合敷料的材料类型、结构、性能、设计考虑和配方策略。我们讨论了最近开发的各种类型的水凝胶敷料，强调了定制其物理化学性质的重要性，并解决了制备多功能水凝胶伤口敷料的潜在挑战。

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.