Association of a novel nutritional index with cognitive impairment in middle-aged and elderly Chinese adults: a cross-sectional analysis from the China Health and Retirement Longitudinal Study.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS Frontiers in Nutrition Pub Date : 2025-02-03 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1486917

Guotao Liu, Jianyuan Zhang

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Abstract

Purpose: The triglyceride-cholesterol-body weight index (TCBI), a novel and easily computable nutritional index, incorporates serum triglyceride (TG), total cholesterol (TC), and body weight (BW). This study explored the association between TCBI and cognitive impairment in middle-aged and elderly Chinese populations.

Patients and methods: This cross-sectional study employed data from the China Health and Retirement Longitudinal Study (CHARLS) baseline survey, including 7,145 participants. TCBI was calculated as TG (mg/dL) × TC (mg/dL) × BW (kg)/1,000. Cognitive function was assessed based on mental status and episodic memory, with a total score below 11 indicating cognitive impairment. The relationship between TCBI and cognitive impairment was examined using multiple logistic regression, smooth curve fitting, and subgroup analyses.

Results: After full adjustment, each 1-unit increase in log-transformed TCBI (Lg TCBI) was associated with a 29.7% reduction in cognitive impairment risk [odds ratio (OR) = 0.703, 95% confidence interval (CI): 0.529-0.933; p = 0.015]. When Lg TCBI was categorized into quartiles, the Q2, Q3, and Q4 groups exhibited a reduced risk of cognitive impairment by 19.9, 16.3, and 22.9%, respectively (p for trend = 0.043), compared to the Q1 group. Smooth curve fitting revealed a consistent decrease in cognitive impairment risk with higher Lg TCBI levels. Subgroup analysis indicated that the association was stronger among participants aged ≥60 years (OR = 0.655, 95% CI: 0.438-0.979), non-current drinkers (OR = 0.643, 95% CI: 0.451-0.917), and those who engaged in socializing (OR = 0.568, 95% CI: 0.371-0.871).

Conclusion: TCBI was significantly and negatively associated with cognitive impairment in Chinese middle-aged and elderly individuals, with the effect more pronounced in those aged ≥60 years, non-current drinkers, and socially active participants.

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一种新的营养指数与中国中老年人认知障碍的关系：来自中国健康与退休纵向研究的横断面分析

目的：甘油三酯-胆固醇-体重指数（TCBI）是一种新型且易于计算的营养指数，包含血清甘油三酯（TG）、总胆固醇（TC）和体重（BW）。本研究探讨中老年人TCBI与认知功能障碍的关系。患者和方法：本横断面研究采用来自中国健康与退休纵向研究（CHARLS）基线调查的数据，包括7,145名参与者。TCBI计算公式为TG （mg/dL） × TC （mg/dL） × BW (kg)/ 1000。认知功能是根据精神状态和情景记忆来评估的，总分低于11分表明认知障碍。采用多元logistic回归、平滑曲线拟合、亚组分析等方法检验TCBI与认知功能障碍的关系。结果：完全调整后，log-transformed TCBI （Lg TCBI）每增加1个单位，认知障碍风险降低29.7%[比值比（OR） = 0.703,95%可信区间（CI）： 0.529-0.933；p = 0.015]。当Lg TCBI被分为四分位数时，与Q1组相比，Q2、Q3和Q4组的认知障碍风险分别降低了19.9%、16.3%和22.9% （p为趋势 = 0.043）。平滑曲线拟合显示，Lg TCBI水平越高，认知障碍风险越低。亚组分析表明，年龄≥60 岁（OR = 0.655,95% CI: 0.438-0.979）、不饮酒（OR = 0.643,95% CI: 0.451-0.917）和参加社交活动（OR = 0.568,95% CI: 0.371-0.871）的参与者的相关性更强。结论：TCBI与中国中老年人认知功能障碍呈显著负相关，在≥60 岁、不饮酒和社交活跃的人群中效果更为明显。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.