Associations between urinary multiple metal concentrations and mitochondrial DNA copy number among occupational workers.

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH International Archives of Occupational and Environmental Health Pub Date : 2025-02-17 DOI:10.1007/s00420-025-02124-z

Zhiping Duan, Qinyu Zhang, Yiming Dai, Jiayun Ding, Changhao Cao, Qiang Hou, Ziqian Yang, Pin Sun, Jiming Zhang, Zhijun Zhou

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引用次数: 0

Abstract

Background: Mitochondrial DNA copy number (mtDNAcn) is an effective biomarker to evaluate the effects of cationic metals on mtDNA integrity and function. In this study, we explored the relationships between individual and combined urinary metal concentrations and mtDNAcn among workers.

Methods: Blood mtDNAcn and urinary metal concentrations were quantified in a cohort of 328 participants. Restricted cubic spline (RCS) models were applied to explore potential non-linear association, while generalized linear models (GLMs) were utilized to assess the associations between urinary metal levels and blood mtDNAcn. We further explored the combined effects of multiple metals on mtDNAcn through quantile g-computation (GQC) and Bayesian kernel machine regression (BKMR).

Results: The dose-response relationship between nickel (Ni) and mtDNAcn exhibited an inverted U-shaped pattern. Notably, GLMs revealed significant reductions in mtDNAcn associated with Ni and silver (Ag) in the second quartile. An overall inverse association between urinary metal mixture and mtDNAcn was observed in the BKMR model when urine dilutions were SG-adjusted. Cre-adjusted lead (Pb) was identified as the primary contributor to decreased mtDNAcn, while SG-adjusted lithium (Li) was indicated as the most substantial contribution to mtDNAcn.

Conclusions: Urinary metal concentrations were associated with decreased mtDNAcn following SG adjustment. Future research should investigate these associations in a larger population with improved calibration techniques.

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来源期刊

International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

6.70%

发文量

127

审稿时长

3 months

期刊介绍： International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.