Elia-Luna Abdo, Imad Ajib, Jason El Mounzer, Mohammad Husseini, Gharam Kalaoun, Tatiana-Maria Matta, Reine Mosleh, Fidel Nasr, Nour Richani, Alia Khalil, Anwar Shayya, Hady Ghanem, Wissam H Faour
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引用次数: 0
Abstract
Introduction: Cancer treatment underwent significant changes in the last few years with the introduction of novel treatments targeting the immune system.
Objectives: The objective of this review is to discuss novel anticancer drugs including kinase inhibitors, biologics and cellular therapy with CAR-T cells.
Methods: Most recent research articles were extracted from PubMed using keywords such as "kinases inhibitors", "CAR-T cell therapy".
Results and discussion: The number of kinase inhibitors is significantly increasing due to their demonstrated effectiveness in combination with biologics. CAR-T represented a major breakthrough in the field. Also, it focused on their mechanisms of action and the rational of their use either alone or in combination in relation to their modes of action.
期刊介绍：
Inflammation Research (IR) publishes peer-reviewed papers on all aspects of inflammation and related fields including histopathology, immunological mechanisms, gene expression, mediators, experimental models, clinical investigations and the effect of drugs. Related fields are broadly defined and include for instance, allergy and asthma, shock, pain, joint damage, skin disease as well as clinical trials of relevant drugs.
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