The Relationship Between the Percent Coefficient of Variation of Sensor Glucose Levels and the Risk of Severe Hypoglycemia or Non-Severe Hypoglycemia in Patients With Type 1 Diabetes: Post Hoc Analysis of the ISCHIA Study.

IF 3.7 Q2 ENDOCRINOLOGY & METABOLISM Journal of Diabetes Science and Technology Pub Date : 2025-02-17 DOI:10.1177/19322968251318756

Takashi Murata, Munehide Matsuhisa, Akio Kuroda, Masao Toyoda, Yushi Hirota, Masahito Ogura, Shota Suzuki, Ken Kato, Atsuhito Tone, Yuka Matoba, Shu Meguro, Junnosuke Miura, Kunihiro Nishimura, Akira Shimada, Kiminori Hosoda, Naoki Sakane

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Abstract

Background: The relationship between the percent coefficient of variation (%CV) and the risk of severe hypoglycemia (SH) or non-severe hypoglycemia (NSH) in patients with type 1 diabetes (T1D) remains to be elucidated.

Materials and methods: The Effect of Intermittent-Scanning Continuous Glucose Monitoring to Glycemic Control Including Hypoglycemia and Quality of Life of Patients with Type 1 Diabetes Mellitus (ISCHIA) study was a crossover, randomized, controlled trial for hypoglycemia prevention in patients with T1D using multiple daily injections (MDIs). Blinded continuous glucose monitoring (CGM) data of 93 patients obtained during the Control period (84 days) were used for the post hoc analysis. The receiver operating characteristics (ROC) curves were analyzed to determine the discrimination thresholds of %CV corresponding to the low blood glucose index (LBGI) > 5 and LBGI ≥ 2.5, and the occurrence of SH.

Results: The %CV corresponding to LBGI > 5 and LBGI ≥ 2.5 was 42.2% and 37.0%, respectively. The episodes of SH were observed in three patients, and the %CV corresponding to the occurrence of SH was 40.7%.

Conclusions: The identification of the discrimination threshold of %CV associated with the risk of SH or NSH in patients with T1D is needed.

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1型糖尿病患者传感器血糖水平百分比变异系数与严重低血糖或非严重低血糖风险的关系：ISCHIA研究的事后分析

背景：1型糖尿病（T1D）患者的百分比变异系数（%CV）与严重低血糖（SH）或非严重低血糖（NSH）风险之间的关系仍有待阐明。材料与方法：间歇扫描连续血糖监测对1型糖尿病患者血糖控制包括低血糖和生活质量的影响（ISCHIA）研究是一项交叉、随机、对照试验，旨在通过每日多次注射（mdi）预防T1D患者低血糖。采用对照期（84天）93例患者的盲法连续血糖监测（CGM）数据进行事后分析。分析受试者工作特征（ROC）曲线，确定低血糖指数(LBGI) > 5和LBGI≥2.5对应的%CV和sh发生的判别阈值。结果：LBGI > 5和LBGI≥2.5对应的%CV分别为42.2%和37.0%。3例患者出现SH发作，对应SH发生的%CV为40.7%。结论：需要确定与T1D患者SH或NSH风险相关的%CV的鉴别阈值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Science and Technology Medicine-Internal Medicine

CiteScore

7.50

自引率

12.00%

发文量

148

期刊介绍： The Journal of Diabetes Science and Technology (JDST) is a bi-monthly, peer-reviewed scientific journal published by the Diabetes Technology Society. JDST covers scientific and clinical aspects of diabetes technology including glucose monitoring, insulin and metabolic peptide delivery, the artificial pancreas, digital health, precision medicine, social media, cybersecurity, software for modeling, physiologic monitoring, technology for managing obesity, and diagnostic tests of glycation. The journal also covers the development and use of mobile applications and wireless communication, as well as bioengineered tools such as MEMS, new biomaterials, and nanotechnology to develop new sensors. Articles in JDST cover both basic research and clinical applications of technologies being developed to help people with diabetes.