Interpreting and comparing neural activity across systems by geometric deep learning

IF 32.1 1区 生物学 Q1 BIOCHEMICAL RESEARCH METHODS Nature Methods Pub Date : 2025-02-17 DOI:10.1038/s41592-024-02581-3
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Abstract

The MARBLE method addresses a critical challenge in neural population recordings: inferring expressive and interpretable latent representations that are comparable across experiments and animals. It achieves this by explicitly leveraging the low-dimensional structure of neural states through geometric deep learning to learn the dynamical flow fields in neural activity.

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通过几何深度学习解释和比较系统间的神经活动。
MARBLE方法解决了神经种群记录中的一个关键挑战:推断在实验和动物之间具有可比性的表达性和可解释性潜在表征。它通过几何深度学习明确地利用神经状态的低维结构来学习神经活动中的动态流场,从而实现了这一点。
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来源期刊
Nature Methods
Nature Methods 生物-生化研究方法
CiteScore
58.70
自引率
1.70%
发文量
326
审稿时长
1 months
期刊介绍: Nature Methods is a monthly journal that focuses on publishing innovative methods and substantial enhancements to fundamental life sciences research techniques. Geared towards a diverse, interdisciplinary readership of researchers in academia and industry engaged in laboratory work, the journal offers new tools for research and emphasizes the immediate practical significance of the featured work. It publishes primary research papers and reviews recent technical and methodological advancements, with a particular interest in primary methods papers relevant to the biological and biomedical sciences. This includes methods rooted in chemistry with practical applications for studying biological problems.
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