Exploring apathy components and their relationship in cognitive decline: insights from a network cross-sectional study.

IF 3 3区心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY BMC Psychology Pub Date : 2025-02-17 DOI:10.1186/s40359-024-02239-x

Pierfrancesco Sarti, Simone Varrasi, Claudia Savia Guerrera, Giuseppe Alessio Platania, Giovanna Furneri, Vittoria Torre, Francesco Maria Boccaccio, Veronica Rivi, Sophie Tascedda, Concetta Pirrone, Mario Santagati, Johanna M C Blom, Sabrina Castellano, Filippo Caraci

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Abstract

Background: Apathy worsens with age and cognitive decline, particularly in Alzheimer's, leading to functional and cognitive deterioration. Comprehending its broad impact is vital for customized, preventive treatments.

Methods: The study examined 214 adults divided in three groups-Mild Cognitive Impairment, mild Alzheimer's, and controls-using neuropsychological tests and questionnaires, with statistical and network analysis to explore apathy's links with other group variables related to demographics and treatment.

Results: Notable differences were observed among the groups' performance of administered tests. While inferential statistics failed to return a predictive model of apathy in mild Alzheimer's, networks and cluster analyses indicate that the demographic variables analysed have different importance at different times of disease progression and that cognitive apathy is particularly prominent in AD-related decline.

Conclusions: Network analysis revealed insights into dementia risk differentiation, notably the impact of sex and demographic factors, beyond the scope of traditional statistics. It highlighted cognitive apathy as a key area for personalized intervention strategies more than behavioural and emotional, emphasizing the importance of short-term goals and not taking away the person's autonomy when not strictly necessary.

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探索认知衰退中冷漠成分及其关系：来自网络横断面研究的见解。

背景：冷漠随着年龄的增长和认知能力的下降而恶化，尤其是在阿尔茨海默氏症中，导致功能和认知能力的恶化。了解其广泛影响对于定制的预防性治疗至关重要。方法：该研究将214名成年人分为三组——轻度认知障碍、轻度阿尔茨海默症和对照组——使用神经心理学测试和问卷调查，通过统计和网络分析来探索冷漠与人口统计学和治疗相关的其他组变量之间的联系。结果：各组在给药测试中的表现有显著差异。虽然推理统计无法给出轻度阿尔茨海默病冷漠的预测模型，但网络和聚类分析表明，所分析的人口统计学变量在疾病进展的不同时期具有不同的重要性，认知冷漠在ad相关衰退中尤为突出。结论：网络分析揭示了痴呆症风险分化的见解，特别是性别和人口因素的影响，超出了传统统计的范围。它强调了认知冷漠是个性化干预策略的一个关键领域，而不是行为和情感，强调了短期目标的重要性，在非必要的情况下不要剥夺人的自主权。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Psychology Psychology-Psychology (all)

CiteScore

3.90

自引率

2.80%

发文量

265

审稿时长

24 weeks

期刊介绍： BMC Psychology is an open access, peer-reviewed journal that considers manuscripts on all aspects of psychology, human behavior and the mind, including developmental, clinical, cognitive, experimental, health and social psychology, as well as personality and individual differences. The journal welcomes quantitative and qualitative research methods, including animal studies.