Serum creatine kinase: requesting and interpreting results.

IF 2.3 Q2 CLINICAL NEUROLOGY PRACTICAL NEUROLOGY Pub Date : 2025-07-14 DOI:10.1136/pn-2024-004422
Jon Walters, Gaafar Gailani
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Abstract

Creatine kinase is an intracellular enzyme found abundantly in skeletal muscle, myocardium and brain. It is well known as a biomarker that increases following skeletal muscle damage and doctors instinctively associate it with myopathies. Serum creatine kinase is undoubtedly often raised in many myopathies and the extent of increase may provide a clue to the myopathic culprit. However, in other myopathies, it may be normal or only marginally raised, and rarely it is normal when the underlying pathology suggests that it should be very raised. Creatine kinase can also be raised in neurogenic disorders, and it can help in the investigation of some neurological disorders that are unrelated to neuromuscular disease. Finally, it may be discovered to be mysteriously elevated without a clear clinical correlate. Here, we examine each of these conundrums, beginning with the clinical problem at hand.

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血清肌酸激酶:请求和解释结果。
肌酸激酶是一种细胞内酶,大量存在于骨骼肌、心肌和大脑中。众所周知,它是骨骼肌损伤后增加的生物标志物,医生本能地将其与肌病联系起来。血清肌酸激酶在许多肌病中无疑经常升高,其升高的程度可能为肌病的罪魁祸首提供线索。然而,在其他肌病中,它可能是正常的或只是轻微升高,当潜在的病理提示它应该非常升高时,它很少是正常的。肌酸激酶也可以在神经源性疾病中升高,它可以帮助研究一些与神经肌肉疾病无关的神经系统疾病。最后,它可能被发现神秘地升高,没有明确的临床关联。在这里,我们从手头的临床问题开始,逐一研究这些难题。
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来源期刊
PRACTICAL NEUROLOGY
PRACTICAL NEUROLOGY Medicine-Neurology (clinical)
CiteScore
3.70
自引率
3.60%
发文量
113
期刊介绍: The essential point of Practical Neurology is that it is practical in the sense of being useful for everyone who sees neurological patients and who wants to keep up to date, and safe, in managing them. In other words this is a journal for jobbing neurologists - which most of us are for at least part of our time - who plough through the tension headaches and funny turns week in and week out. Primary research literature potentially relevant to routine clinical practice is far too much for any neurologist to read, let alone understand, critically appraise and assimilate. Therefore, if research is to influence clinical practice appropriately and quickly it has to be digested and provided to neurologists in an informative and convenient way.
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