Hemiphosphoindigos as a platform for chiroptical or water soluble photoswitching

IF 15.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Nature Communications Pub Date : 2025-02-19 DOI:10.1038/s41467-025-56942-3

Fabien Kohl, Theresa Vogl, Frank Hampel, Henry Dube

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Abstract

Photoswitches are important molecular tools to precisely control the behavior of matter by using light irradiation. They have found application in virtually all applied chemical fields from chemical biology to material sciences. However, great challenges remain in advanced property design including tailored chiroptical responses or water solubility. Here, hemiphosphoindigo (HPI) photoswitches are presented as capable phosphorus-based photoswitches and a distinct addition to the established indigoid chromophore family. Phosphinate is embedded in the core indigoid chromophore and the resulting optimized photoswitches display high thermal stabilities, excellent fatigue resistance and high isomer enrichment. A series of planar, twisted and heterocyclic HPIs are investigated to probe design strategies for advantageous photophysical properties. The phosphinate provides a platform for easily accessible, water-soluble photoswitches, especially interesting for biological applications. Its chiral nature further allows light-induced modulation of chiroptical properties. HPIs therefore open up a distinct structural space for photoswitch generation and advanced light-responsive applications.

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作为热敏或水溶性光开关平台的半磷靛蓝

光开关是利用光照射精确控制物质行为的重要分子工具。它们在从化学生物学到材料科学的几乎所有应用化学领域都有应用。然而，在先进的性能设计方面仍然存在巨大的挑战，包括量身定制的热效应或水溶性。在这里，半磷靛蓝（HPI）光开关被呈现为能够基于磷的光开关，并且是已建立的靛蓝发色团家族的独特补充。将膦酸盐嵌入核心靛蓝发色团中，所得到的优化光开关具有高热稳定性、优异的抗疲劳性和高异构体富集性。研究了一系列平面、扭曲和杂环hpi，以探索具有良好光物理性质的设计策略。膦酸盐为易于获取的水溶性光开关提供了一个平台，尤其对生物应用感兴趣。它的手性进一步允许光诱导的手性调制。因此，hpi为光开关的产生和先进的光响应应用开辟了一个独特的结构空间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.