Glutathione and tyrosinase Co-activated near-infrared fluorescent probes for precise detection of melanoma

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED Dyes and Pigments Pub Date : 2025-02-16 DOI:10.1016/j.dyepig.2025.112712

Dan Wu , Chao Gan , Chao He , Yan Wu , Peng-Yu Ji , Cheng Xing , Li-Qiong Yao

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Abstract

Melanoma is a highly aggressive malignant tumor, and precise diagnosis is essential but remains to be explored. Making full use of the widespread correlation biomarker in melanoma to develop the dual-locked NIR fluorescence probe is of great importance for the accurate diagnosis and treatment of melanoma. Herein, we proposed a novel dual-locked NIR fluorescent probe Cy-Dual by utilizing two interrelated characteristic biomarkers of melanoma. Cy-Dual remained fluorescent off in normal cells, yet turn on remarkable NIR fluorescence after the co-activation of two melanoma-associated markers, namely, glutathione and tyrosinase. In-depth cell bioimaging results indicate that Cy-Dual allows highly specific imaging of melanoma cells, making it a powerful tool for accurately detecting melanomas. More impressively, such co-activated probe further enables the real-time imaging diagnosis of melanoma in vivo utilizing a xenograft tumor-bearing mice model. This study provides a non-invasive imaging technique for melanoma, which facilitates advancements in precision medicine related to melanoma.

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.