{"title":"The unconventional role of vimentin intermediate filaments","authors":"Xinyi Huang , Shuangshuang Zhao , Yifan Xing , Xuedi Gao , Chenglin Miao , Yuhan Huang , Yaming Jiu","doi":"10.1016/j.ceb.2025.102483","DOIUrl":null,"url":null,"abstract":"<div><div>Vimentin, a type III intermediate filament (IF) protein, is well-recognized for its role at the intersection of structural biology and cellular dynamics, influencing various pathways that determine cell fate and function. While these functions have been extensively characterized, there is still limited understanding of vimentin's broader impact beyond its traditional cytoskeletal roles in regulating a spectrum of cellular processes. This review explores the novel and unconventional roles of vimentin, with a focus on its extracellular functions, membrane receptor properties, and regulatory influence on gene expression and cellular metabolism.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"93 ","pages":"Article 102483"},"PeriodicalIF":6.0000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0955067425000213","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Vimentin, a type III intermediate filament (IF) protein, is well-recognized for its role at the intersection of structural biology and cellular dynamics, influencing various pathways that determine cell fate and function. While these functions have been extensively characterized, there is still limited understanding of vimentin's broader impact beyond its traditional cytoskeletal roles in regulating a spectrum of cellular processes. This review explores the novel and unconventional roles of vimentin, with a focus on its extracellular functions, membrane receptor properties, and regulatory influence on gene expression and cellular metabolism.
期刊介绍：
Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings.
COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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