Organometallic-based pyroptotic inducers for cancer immunotherapy

Abstract

Cancer immunotherapy has been emerging as promising modality to treat malignant tumors, but the solid tumors with the “immune-cold” or immune-excluded nature induce the presence of the individual therapy discrepancy among patients. Pyroptosis, launched by gasdermin proteins, is favorable to trigger membrane perforation followed by the release of pro-inflammatory cytokines, which further induces antitumor immunity. Significantly, organometallic-based structures have been recently developed and exhibited the capacity of the pyroptotic activation through the acute redox homeostasis, which has been rising as an effective strategy for cancer immunotherapy. Up to date, few review has focused on this field. Therefore, this review provides a concentrated summary and discussion of the most recent works about organometallic-based pyroptotic activation. We hope that this review will be helpful to the readership who are interested in learning more about pyroptosis and the development of metal based pyroptotic inducers to efficiently augment the therapeutic efficacy.