{"title":"Surgical versus medical treatment of drug resistant epilepsy in children: Seizure and non-seizure outcomes","authors":"M.Scott Perry , Dax Bourcier , Paula Brna","doi":"10.1016/j.yebeh.2025.110269","DOIUrl":null,"url":null,"abstract":"<div><div>The goal of epilepsy treatment is to achieve the most significant seizure reduction, aiming for seizure freedom, in the absence of consequential adverse effects. For children with drug resistant epilepsy (DRE), surgical therapy may offer the best chance of seizure freedom, but is vastly underutilized. In cases where seizure freedom is not possible, surgery may still provide meaningful seizure reduction over that expected from continued medical management. In addition, seizure freedom and reduction can have meaningful impact on non-seizure outcomes including mortality, cognition, behavior, and cost of care. It is essential to compare the relative risks and benefits of continued medical therapy versus surgical therapy in order to best inform choice of treatment in pediatric DRE and avoid unnecessary delays. In this review, we explore the seizure and non-seizure benefits of epilepsy surgery, including curative procedures and those expected to result in meaningful seizure reduction, compared to continued medical management in children.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110269"},"PeriodicalIF":2.3000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epilepsy & Behavior","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1525505025000083","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
The goal of epilepsy treatment is to achieve the most significant seizure reduction, aiming for seizure freedom, in the absence of consequential adverse effects. For children with drug resistant epilepsy (DRE), surgical therapy may offer the best chance of seizure freedom, but is vastly underutilized. In cases where seizure freedom is not possible, surgery may still provide meaningful seizure reduction over that expected from continued medical management. In addition, seizure freedom and reduction can have meaningful impact on non-seizure outcomes including mortality, cognition, behavior, and cost of care. It is essential to compare the relative risks and benefits of continued medical therapy versus surgical therapy in order to best inform choice of treatment in pediatric DRE and avoid unnecessary delays. In this review, we explore the seizure and non-seizure benefits of epilepsy surgery, including curative procedures and those expected to result in meaningful seizure reduction, compared to continued medical management in children.
期刊介绍：
Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy.
Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging.
From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.
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