Investigation of the effects of propofol and sevoflurane anesthesia on oxidant-antioxidant status and biochemical parameters in Turkish hair goats.

IF 1.4 3区农林科学 Q2 VETERINARY SCIENCES American journal of veterinary research Pub Date : 2025-02-17 Print Date: 2025-05-01 DOI:10.2460/ajvr.24.10.0309

Ali Gülaydın, Kıvanç İrak, Nihat Şındak, Mustafa Barış Akgül, Özgür Yaşar Çelik, Onur Yıldırım, Maruf Yılmaz, Erman Gülendağ

{"title":"Investigation of the effects of propofol and sevoflurane anesthesia on oxidant-antioxidant status and biochemical parameters in Turkish hair goats.","authors":"Ali Gülaydın, Kıvanç İrak, Nihat Şındak, Mustafa Barış Akgül, Özgür Yaşar Çelik, Onur Yıldırım, Maruf Yılmaz, Erman Gülendağ","doi":"10.2460/ajvr.24.10.0309","DOIUrl":null,"url":null,"abstract":"Objective: To investigate the effects of propofol and sevoflurane anesthesia on the oxidant-antioxidant status and biochemical parameters in Turkish hair goats.Methods: The study was conducted from February 15 through March 15, 2024. Seven clinically healthy female Turkish hair goats aged 1 to 2 years with an average live weight of 29.95 (26.1 to 33.8) kg were included. A bolus of propofol (6 mg/kg) was injected IV. The goats were placed in the sternoabdominal position and administered 1% to 3% sevoflurane with 100% oxygen for 2 hours with the help of a vaporizer. Blood samples were collected before and after the administration of propofol and at the 15th, 30th, 60th, and 120th minutes after the start of sevoflurane administration in nonanticoagulated tubes. The oxidant-antioxidant status (serum total antioxidant status, total oxidant status, paraoxonase activity, and arylesterase activity) and biochemical parameters (levels of glucose, AST, GGT, ALT, ALP, LDH, creatine kinase, amylase, lipase, creatinine, urea, uric acid, high-density lipoprotein, low-density lipoprotein, total protein, albumin, total bilirubin, direct bilirubin, magnesium, chlorine, calcium, iron, sodium, phosphorus, and potassium) were evaluated. The heart rate, respiratory rate, and body temperature of the goats were measured using a bedside monitor.Results: Arylesterase activity increased with sevoflurane administration. Changes were observed in heart rate and body temperature as well as in the levels of glucose, creatine kinase, urea, total bilirubin, and potassium at different time intervals of propofol-sevoflurane administration.Conclusions: Propofol-sevoflurane anesthesia has no adverse effects on oxidant-antioxidant status in Turkish hair goats.Clinical relevance: The evaluation of heart rate and body temperature, as well as glucose, creatine kinase, urea, total bilirubin, and potassium levels, must be considered in propofol-sevoflurane anesthesia protocol.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of veterinary research","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.2460/ajvr.24.10.0309","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/1 0:00:00","PubModel":"Print","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To investigate the effects of propofol and sevoflurane anesthesia on the oxidant-antioxidant status and biochemical parameters in Turkish hair goats.

Methods: The study was conducted from February 15 through March 15, 2024. Seven clinically healthy female Turkish hair goats aged 1 to 2 years with an average live weight of 29.95 (26.1 to 33.8) kg were included. A bolus of propofol (6 mg/kg) was injected IV. The goats were placed in the sternoabdominal position and administered 1% to 3% sevoflurane with 100% oxygen for 2 hours with the help of a vaporizer. Blood samples were collected before and after the administration of propofol and at the 15th, 30th, 60th, and 120th minutes after the start of sevoflurane administration in nonanticoagulated tubes. The oxidant-antioxidant status (serum total antioxidant status, total oxidant status, paraoxonase activity, and arylesterase activity) and biochemical parameters (levels of glucose, AST, GGT, ALT, ALP, LDH, creatine kinase, amylase, lipase, creatinine, urea, uric acid, high-density lipoprotein, low-density lipoprotein, total protein, albumin, total bilirubin, direct bilirubin, magnesium, chlorine, calcium, iron, sodium, phosphorus, and potassium) were evaluated. The heart rate, respiratory rate, and body temperature of the goats were measured using a bedside monitor.

Results: Arylesterase activity increased with sevoflurane administration. Changes were observed in heart rate and body temperature as well as in the levels of glucose, creatine kinase, urea, total bilirubin, and potassium at different time intervals of propofol-sevoflurane administration.

Conclusions: Propofol-sevoflurane anesthesia has no adverse effects on oxidant-antioxidant status in Turkish hair goats.

Clinical relevance: The evaluation of heart rate and body temperature, as well as glucose, creatine kinase, urea, total bilirubin, and potassium levels, must be considered in propofol-sevoflurane anesthesia protocol.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

异丙酚和七氟醚麻醉对土耳其毛山羊氧化-抗氧化状态和生化指标影响的研究。

目的：探讨异丙酚和七氟醚麻醉对土耳其毛山羊氧化-抗氧化状态及生化指标的影响。方法：研究时间为2024年2月15日至3月15日。选取7只临床健康的1 ~ 2岁雌性土耳其毛山羊，平均活重29.95 (26.1 ~ 33.8)kg。静脉注射异丙酚1丸（6 mg/kg）。山羊置于胸腹位，在汽化器的帮助下给予1% ~ 3%七氟醚加100%氧气2小时。分别于异丙酚给药前后和七氟醚非抗凝管给药后15、30、60、120分钟采集血样。评估氧化-抗氧化状态（血清总抗氧化状态、总氧化状态、对氧磷酶活性和芳酰酯酶活性）和生化参数（葡萄糖、AST、GGT、ALT、ALP、LDH、肌酸激酶、淀粉酶、脂肪酶、肌酐、尿素、尿酸、高密度脂蛋白、低密度脂蛋白、总蛋白、白蛋白、总胆红素、直接胆红素、镁、氯、钙、铁、钠、磷、钾）水平。使用床边监护仪测量山羊的心率、呼吸频率和体温。结果：芳烯酯酶活性随七氟醚浓度升高而升高。观察异丙酚-七氟醚给药不同时间间隔心率、体温、葡萄糖、肌酸激酶、尿素、总胆红素、钾水平的变化。结论：异丙酚-七氟醚麻醉对土耳其毛山羊的氧化-抗氧化状态无不良影响。临床相关性：在异丙酚-七氟醚麻醉方案中，必须考虑评估心率和体温，以及葡萄糖、肌酸激酶、尿素、总胆红素和钾水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

American journal of veterinary research 农林科学-兽医学

CiteScore

1.70

自引率

10.00%

发文量

186

审稿时长

3 months

期刊介绍： The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.