E. Valdivieso, M. Zabala, A. Muñoz Noval, R. López-Méndez, N. Carmona, A. Espinosa, F. J. García García, K. Boulahya, J. A. Lucas, L. Biancotto, U. Amador, M. T. Azcondo, C. Hurtado-Marcos
{"title":"Hyperthermic Core-Shell Silver-Gold Nanoparticles: Green Synthesis and Adsorption-Uptake by Macrophages, Fibroblasts and Cancer Cells","authors":"E. Valdivieso, M. Zabala, A. Muñoz Noval, R. López-Méndez, N. Carmona, A. Espinosa, F. J. García García, K. Boulahya, J. A. Lucas, L. Biancotto, U. Amador, M. T. Azcondo, C. Hurtado-Marcos","doi":"10.1002/open.202400459","DOIUrl":null,"url":null,"abstract":"<p>Gold-coated silver nanoparticles (Ag@AuNPs) are synthesized by green synthesis using <i>Vaccinium corymbosum</i> as reducing agent. The obtained Ag@AuNPs present a core-shell structure with nanostar shape. The absorption spectrum of these nanoparticles shows a prominent band centred at 680 nm, within the optimal range for photothermal applications. Dispersions of Ag@AuNPs in water, 1.87 10<sup>10</sup> NPs/mL, reach a temperature of 44.3 °C under laser excitation in 10 minutes, which is suitable for hyperthermia therapy. The internalization of Ag@AuNPs, at a concentration of 3 10<sup>8</sup> NPs/ml, by macrophages (Raw 264.7), human fibroblasts (Hs27), and cancer cells (4T1) is confirmed by transmission electron microscopy. Cytotoxicity studies demonstrate that at this concentration the cells are viable.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"14 3","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/open.202400459","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemistryOpen","FirstCategoryId":"92","ListUrlMain":"https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/open.202400459","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Gold-coated silver nanoparticles (Ag@AuNPs) are synthesized by green synthesis using Vaccinium corymbosum as reducing agent. The obtained Ag@AuNPs present a core-shell structure with nanostar shape. The absorption spectrum of these nanoparticles shows a prominent band centred at 680 nm, within the optimal range for photothermal applications. Dispersions of Ag@AuNPs in water, 1.87 1010 NPs/mL, reach a temperature of 44.3 °C under laser excitation in 10 minutes, which is suitable for hyperthermia therapy. The internalization of Ag@AuNPs, at a concentration of 3 108 NPs/ml, by macrophages (Raw 264.7), human fibroblasts (Hs27), and cancer cells (4T1) is confirmed by transmission electron microscopy. Cytotoxicity studies demonstrate that at this concentration the cells are viable.
期刊介绍：
ChemistryOpen is a multidisciplinary, gold-road open-access, international forum for the publication of outstanding Reviews, Full Papers, and Communications from all areas of chemistry and related fields. It is co-owned by 16 continental European Chemical Societies, who have banded together in the alliance called ChemPubSoc Europe for the purpose of publishing high-quality journals in the field of chemistry and its border disciplines. As some of the governments of the countries represented in ChemPubSoc Europe have strongly recommended that the research conducted with their funding is freely accessible for all readers (Open Access), ChemPubSoc Europe was concerned that no journal for which the ethical standards were monitored by a chemical society was available for such papers. ChemistryOpen fills this gap.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
