E Valdivieso, M Zabala, A Muñoz Noval, R López-Méndez, N Carmona, A Espinosa, F J García García, K Boulahya, J A Lucas, L Biancotto, U Amador, M T Azcondo, C Hurtado-Marcos
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引用次数: 0
Abstract
Gold-coated silver nanoparticles (Ag@AuNPs) are synthesized by green synthesis using Vaccinium corymbosum as reducing agent. The obtained Ag@AuNPs present a core-shell structure with nanostar shape. The absorption spectrum of these nanoparticles shows a prominent band centred at 680 nm, within the optimal range for photothermal applications. Dispersions of Ag@AuNPs in water, 1.87 1010 NPs/mL, reach a temperature of 44.3 °C under laser excitation in 10 minutes, which is suitable for hyperthermia therapy. The internalization of Ag@AuNPs, at a concentration of 3 108 NPs/ml, by macrophages (Raw 264.7), human fibroblasts (Hs27), and cancer cells (4T1) is confirmed by transmission electron microscopy. Cytotoxicity studies demonstrate that at this concentration the cells are viable.
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