Increased risk of dementia in Type 1 diabetes: A systematic review with meta-analysis.

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes research and clinical practice Pub Date : 2025-02-16 DOI:10.1016/j.diabres.2025.112043

Lily Li, Dana Wong, Caroline A Fisher, Jennifer J Conn, Paul R Wraight, Alexandra Davies, Elizabeth Barson, Kerryn E Pike

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Abstract

This systematic review and meta-analysis aimed to synthesize evidence on the association between Type 1 diabetes mellitus (Type 1 diabetes) and dementia risk. A systematic search of CINAHL, EMBASE, MEDLINE, PSYCINFO, and Web of Science databases identified 19 relevant studies for inclusion. Studies, published in English, were assessed for quality using the QUADAS-2 tool, and data were extracted for synthesis. A meta-analysis of six studies reporting hazard ratios (HR) for dementia risk in individuals with Type 1 diabetes versus controls was conducted. The pooled HR for all-cause dementia was 1.50 (95 % CI: 1.25-1.80, p < 0.001), indicating a 50 % increased risk of dementia in people with Type 1 diabetes compared to controls. This review provides robust evidence linking Type 1 diabetes to increased dementia risk and highlights the need for targeted screening and preventive strategies for this population. Further research is necessary to explore the mechanisms underlying the association between T1DM and dementia.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.