Magnetic Resonance-Guided Focused Ultrasound Treatment for Essential Tremor: A Single-Center Experience.

IF 2.6 4区医学 Q2 CLINICAL NEUROLOGY Movement Disorders Clinical Practice Pub Date : 2025-02-19 DOI:10.1002/mdc3.70012

Victor S Hvingelby, Pernille Kjeldsen, Bo Bergholt, Gaston Andres Schechtmann, Erik Hvid Danielsen, Mette Møller, Erik Lisbjerg Johnsen, Skirmante Mardosiene, Torben Ellegaard Lund, Dora Grauballe, Michael Geneser, Tina Vincens Sørensen, Lisa Østergaard Bak, Martin Andreasen, Anne Sofie Møller Andersen, Lone Andersen, Kaare Meier, Niels Juhl, Alp Tankisi, Bo Jespersen, Christian Fenger Eriksen, Mads Rasmussen, Winnie Bechmann Eriksen, Birgitte Barrutia, Mette Kromann, Ida Baandrup, Jette Bjørn, Rie Stjernholm, Charlotte Bræmer-Madsen, Signe Mygdal Jørgensen, Jens Christian Hedemann Sørensen, Andreas Nørgaard Glud

{"title":"Magnetic Resonance-Guided Focused Ultrasound Treatment for Essential Tremor: A Single-Center Experience.","authors":"Victor S Hvingelby, Pernille Kjeldsen, Bo Bergholt, Gaston Andres Schechtmann, Erik Hvid Danielsen, Mette Møller, Erik Lisbjerg Johnsen, Skirmante Mardosiene, Torben Ellegaard Lund, Dora Grauballe, Michael Geneser, Tina Vincens Sørensen, Lisa Østergaard Bak, Martin Andreasen, Anne Sofie Møller Andersen, Lone Andersen, Kaare Meier, Niels Juhl, Alp Tankisi, Bo Jespersen, Christian Fenger Eriksen, Mads Rasmussen, Winnie Bechmann Eriksen, Birgitte Barrutia, Mette Kromann, Ida Baandrup, Jette Bjørn, Rie Stjernholm, Charlotte Bræmer-Madsen, Signe Mygdal Jørgensen, Jens Christian Hedemann Sørensen, Andreas Nørgaard Glud","doi":"10.1002/mdc3.70012","DOIUrl":null,"url":null,"abstract":"Background: Essential tremor is the most common hyperkinetic movement disorder. Magnetic resonance imaging-guided focused ultrasound (MRgFUS) has emerged as second-line therapy.Objective: The aim was to obtain the results of the first 108 patients treated with MRgFUS in Denmark.Methods: Data were entered in a quality assurance database at baseline and 3, 6, and 12 months. Clinician- and patient-rated treatment efficacy was evaluated using the Fahn-Marin-Tolosa (FMT) scale and the Patient Global Impression of Change.Results: A total of 108 persons have currently been treated. Tremor improved by a total mean 6.39 points (95% confidence interval [CI]: 5.01;7.76, P < 0.00001) and 9.63 points (95% CI: 7.60;11.66, P < 0.00001), 10.42 (95% CI: 9.06;11.79, P < 0.00001), and 26.45 (95% CI: 22.46;30.43, P < 0.00001) for FMT parts A, B, and C, respectively, at 3 months. Side effects occurred in 65.7% of patients at 3 months and 33.7% at 12 months.Conclusion: Our findings are in line with existing evidence. Questions regarding persistence of gait- and balance-related side effects remain.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Movement Disorders Clinical Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/mdc3.70012","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Essential tremor is the most common hyperkinetic movement disorder. Magnetic resonance imaging-guided focused ultrasound (MRgFUS) has emerged as second-line therapy.

Objective: The aim was to obtain the results of the first 108 patients treated with MRgFUS in Denmark.

Methods: Data were entered in a quality assurance database at baseline and 3, 6, and 12 months. Clinician- and patient-rated treatment efficacy was evaluated using the Fahn-Marin-Tolosa (FMT) scale and the Patient Global Impression of Change.

Results: A total of 108 persons have currently been treated. Tremor improved by a total mean 6.39 points (95% confidence interval [CI]: 5.01;7.76, P < 0.00001) and 9.63 points (95% CI: 7.60;11.66, P < 0.00001), 10.42 (95% CI: 9.06;11.79, P < 0.00001), and 26.45 (95% CI: 22.46;30.43, P < 0.00001) for FMT parts A, B, and C, respectively, at 3 months. Side effects occurred in 65.7% of patients at 3 months and 33.7% at 12 months.

Conclusion: Our findings are in line with existing evidence. Questions regarding persistence of gait- and balance-related side effects remain.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

求助全文

约1分钟内获得全文去求助

来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)