Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics†

IF 10.6 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Natural Product Reports Pub Date : 2024-12-02 Epub Date: 2025-02-20 DOI:10.1039/d4np00064a

Morgane Mauduit , Stéphane Greff , Marie Derrien , Charlotte Simmler

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Abstract

Covering: 1982 up to the end of 2024

Marine exometabolites (EMs) are small molecules released by marine (micro)organisms into the seawater. Collectively, all of the released EMs contribute to the chemical seascape of a marine ecosystem. Accessing and describing these waterborne molecules are a key focus of various disciplinary fields that aim to study marine biogeochemical cycles, translate the chemical language of the oceans (chemical ecology), or discover new structural entities with biological properties (natural product discovery). Beginning with the semantics of marine exometabolites, this review elucidates the different sampling methods and MS-based metabolomic analyses that are used to describe the chemical composition of seawater of benthic ecosystems. These technical and analytical advances offer promising avenues for describing the structural diversity of marine exometabolites and deciphering their functions in various ecological contexts.

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描述底栖海水的复杂化学：从外代谢物取样策略到基于质谱的代谢组学。

海洋外代谢物（EMs）是由海洋（微生物）生物释放到海水中的小分子。总的来说，所有释放的化学物质都对海洋生态系统的化学景观有贡献。获取和描述这些水生分子是各个学科领域的重点，旨在研究海洋生物地球化学循环，翻译海洋化学语言（化学生态学），或发现具有生物特性的新结构实体（天然产物发现）。本文从海洋外代谢物的语义入手，阐述了用于描述底栖生态系统海水化学成分的不同采样方法和基于质谱的代谢组学分析。这些技术和分析的进步为描述海洋外代谢物的结构多样性和破译它们在各种生态环境中的功能提供了有希望的途径。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.