Asha Budakoti, Priyankar Jha, Meenakshi Verma, Prema G Vasudev, Atul Gupta
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引用次数: 0
Abstract
Bridged bicyclo[3.3.1]nonanes having the O,O-ketal subunit are widely found in medicinal compounds. While several acid-catalyzed approaches have been reported for the construction of ketals, this study discloses an imidazole-catalyzed modular construction of bicyclo[3.3.1]nonanes from naphthols/phenols and 3-acyl-2-hydroxyl chromenes. The proposed reaction pathway follows a formal [3 + 3] cycloaddition of phenols and an oxonium dipolar intermediate. The reaction is efficient regarding scalability, environmentally benign conditions, and resulting in the products in good to excellent yields.
期刊介绍：
Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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