{"title":"Blood rheology and systemic oxidative status in patients with acromegaly.","authors":"Emine Kilic-Toprak, Guzin Fidan Yaylali, Yasin Ozdemir, Senay Topsakal, Ozgen Kilic-Erkek, Burak Oymak, Melek Bor-Kucukatay","doi":"10.1177/0006355X241290980","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular system is known to be affected in acromegaly. However, it was not reported to date if hemorheology was also altered and there is limited data regarding systemic oxidative status in patients with acromegaly.</p><p><strong>Objective: </strong>To investigate alterations in hemorheology and systemic oxidative stress in patients with acromegaly.</p><p><strong>Methods: </strong>The study comprised 19 active (AA) and 15 controlled (CA) acromegaly patients (n = 34, mean age 48.85 ± 1.69 years) and 29 controls (mean age 52.83 ± 1.37 years). Erythrocyte aggregation index (AI), aggregation half time (t½), amplitude (Amp) and erythrocyte elongation index (EI) were determined by an ektacytometer. Commercial kits were used for measuring serum total oxidant status (TOS) and total antioxidant status (TAS), and oxidative stress index (OSI) was calculated.</p><p><strong>Results: </strong>There were statistically significant differences regarding EI at shear stresses of 16.87 ve 30.00 Pa (p = 0.034, p = 0.0001, respectively) and AI (p = 0.050, p = 0.035, respectively) values among the control, AA and CA groups. Decrement of t½ was in line with increment of AI and indicated increased erythrocyte aggregation. Serum TOS, TAS and OSI values were similar between the control, AA and CA groups (p > 0.05).</p><p><strong>Conclusions: </strong>This pilot study demonstrated reduced erythrocyte deformability and increased erythrocyte aggregation in patients with AA and CA.</p>","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":" ","pages":"6355X241290980"},"PeriodicalIF":1.0000,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biorheology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/0006355X241290980","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOPHYSICS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Cardiovascular system is known to be affected in acromegaly. However, it was not reported to date if hemorheology was also altered and there is limited data regarding systemic oxidative status in patients with acromegaly.
Objective: To investigate alterations in hemorheology and systemic oxidative stress in patients with acromegaly.
Methods: The study comprised 19 active (AA) and 15 controlled (CA) acromegaly patients (n = 34, mean age 48.85 ± 1.69 years) and 29 controls (mean age 52.83 ± 1.37 years). Erythrocyte aggregation index (AI), aggregation half time (t½), amplitude (Amp) and erythrocyte elongation index (EI) were determined by an ektacytometer. Commercial kits were used for measuring serum total oxidant status (TOS) and total antioxidant status (TAS), and oxidative stress index (OSI) was calculated.
Results: There were statistically significant differences regarding EI at shear stresses of 16.87 ve 30.00 Pa (p = 0.034, p = 0.0001, respectively) and AI (p = 0.050, p = 0.035, respectively) values among the control, AA and CA groups. Decrement of t½ was in line with increment of AI and indicated increased erythrocyte aggregation. Serum TOS, TAS and OSI values were similar between the control, AA and CA groups (p > 0.05).
Conclusions: This pilot study demonstrated reduced erythrocyte deformability and increased erythrocyte aggregation in patients with AA and CA.
期刊介绍：
Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The scope of papers solicited by Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
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