Distinct insula subdivisions of resting-state functional connectivity in individuals with opioid and methamphetamine use disorders.

IF 2.9 2区医学 Q2 NEUROSCIENCES Cerebral cortex Pub Date : 2025-02-05 DOI:10.1093/cercor/bhaf014

Wenhan Yang, Xinwen Wen, Zhe Du, Longtao Yang, Yanjing Chen, Jun Zhang, Kai Yuan, Jun Liu

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Abstract

Different addictive drugs can impact the function and morphology of the brain in diverse ways. The insula cortex, an important brain node involved in craving and reward neural circuits in individuals with substance use disorders (including damage to the insula cortex), has been reported to reduce addictive behaviors. However, less is known about whether there is a functional difference between individuals with opioid and methamphetamine use disorders, especially regarding the function of the insula cortex. Fifty-eight individuals with opioid use disorder and sixty individuals with methamphetamine use disorder underwent resting-state and 3D-T1-weighted magnetic resonance imaging and completed craving questionnaires. Differences in insula subdivision resting-state functional connectivity between the groups were assessed, and their correlations with craving were analyzed. Compared with the methamphetamine group, the opioid group demonstrated increased connectivity of the right dorsal anterior insula but decreased connectivity of the right posterior insula and the left dorsal anterior insula/posterior insula/ventral anterior insula. Additionally, a negative correlation between functional connectivity and craving was observed in individuals with opioid and methamphetamine use disorders. This study provides insights into the various brain function connection patterns that are associated with different types of drug use with respect to opioid and methamphetamine use disorders.

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阿片类药物和甲基苯丙胺使用障碍个体静息状态功能连接的不同脑岛细分。

不同的成瘾药物会以不同的方式影响大脑的功能和形态。脑岛皮质是物质使用障碍（包括脑岛皮质损伤）患者的一个重要脑节点，与渴望和奖励神经回路有关，据报道，它可以减少成瘾行为。然而，对于阿片类药物和甲基苯丙胺使用障碍患者之间是否存在功能差异，特别是关于脑岛皮质的功能，人们知之甚少。对58名阿片类药物使用障碍患者和60名甲基苯丙胺使用障碍患者进行静置状态和3d - t1加权磁共振成像，并完成渴望问卷。评估各组之间脑岛细分静息状态功能连通性的差异，并分析其与渴望的相关性。与甲基苯丙胺组相比，阿片类药物组右脑前背岛的连通性增加，而右脑后岛和左脑前背岛/后岛/前腹岛的连通性降低。此外，在阿片类药物和甲基苯丙胺使用障碍的个体中，观察到功能连接与渴望之间的负相关。这项研究提供了对阿片类药物和甲基苯丙胺使用障碍中与不同类型药物使用相关的各种脑功能连接模式的见解。亮点:

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebral cortex 医学-神经科学

CiteScore

6.30

自引率

8.10%

发文量

510

审稿时长

2 months

期刊介绍： Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.