Household cleaning agents impact on pediatric asthma: a systematic review and meta-analysis.

IF 1.9 4区医学 Q3 ENVIRONMENTAL SCIENCES International Journal of Environmental Health Research Pub Date : 2025-10-01 Epub Date: 2025-02-19 DOI:10.1080/09603123.2025.2467820

Muhammad Imran Arif, Zhi Yuan Wang, Liang Ru

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Abstract

Background: Household cleaning agents promote hygiene along with causing respiratory effects, especially pediatric asthma. This systematic review quantified the association between exposure to household cleaning agents and pediatric asthma.

Method: Five databases were searched. Data were analyzed qualitatively and quantitatively. RevMan 5.4 calculated odds ratios (OR) with 95% confidence intervals (CI), and a funnel plot assessed publication bias. The Mixed Methods Appraisal Tool (MMAT) and GRADE framework assessed methodological quality and certainty respectively.

Results: Sixteen studies met the eligibility criteria. Meta-analysis showed a significant association between the use of household cleaning agents and pediatric asthma (OR 2.90 (95% CI: 2.13-3.95; p < 0.01, I² = 98%). Exposure stages also showed significant (p < 0.01) association with household cleaning agents (OR 2.92 (95% CI: 2.12-4.03, I² = 98%). No publication bias or high risk of bias was found.

Conclusion: A strong association between exposure to household cleaning agents and an increased risk of pediatric asthma was found. .

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家用清洁剂对儿童哮喘的影响：一项系统综述和荟萃分析。

背景：家用清洁剂促进卫生的同时引起呼吸系统的影响，尤其是儿童哮喘。本系统综述量化了暴露于家用清洁剂和儿童哮喘之间的关系。方法：检索5个数据库。对数据进行定性和定量分析。RevMan 5.4以95%可信区间（CI）计算比值比（OR），并使用漏斗图评估发表偏倚。混合方法评估工具（MMAT）和GRADE框架分别评估方法质量和确定性。结果：16项研究符合入选标准。荟萃分析显示，使用家用清洁剂与儿童哮喘之间存在显著关联（OR 2.90） (95% CI: 2.13-3.95；p2 = 98%)。暴露阶段也有显著性差异（p 2 = 98%）。未发现发表偏倚或高偏倚风险。结论：发现家庭清洁剂暴露与儿童哮喘风险增加之间存在密切联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.